{"id":"yellow-fever-vaccine-institut-pasteur","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"10-20","effect":"Myalgia"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Injection site reaction"},{"rate":"5-10","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL2108816","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Yellow fever vaccine (Institut Pasteur strain) contains a weakened live yellow fever virus that replicates in vaccinated individuals without causing disease. This triggers both humoral (antibody) and cell-mediated immune responses, providing protective immunity against infection with wild-type yellow fever virus. A single dose typically confers lifelong immunity in most recipients.","oneSentence":"The vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus through a live attenuated viral strain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:25.999Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of yellow fever in travelers to endemic regions"},{"name":"Prevention of yellow fever in at-risk populations in endemic areas"}]},"trialDetails":[{"nctId":"NCT04059471","phase":"PHASE4","title":"Non- Inferiority Fractional-doses Trial for Yellow Fever Vaccine","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2019-11-11","conditions":"Yellow Fever","enrollment":900},{"nctId":"NCT02991495","phase":"PHASE4","title":"Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines (YEFE)","status":"COMPLETED","sponsor":"Epicentre","startDate":"2017-11-06","conditions":"Yellow Fever","enrollment":1630}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Children sub-study"],"phase":"marketed","status":"active","brandName":"Yellow fever vaccine, Institut Pasteur","genericName":"Yellow fever vaccine, Institut Pasteur","companyName":"University of Oxford","companyId":"university-of-oxford","modality":"Biologic","firstApprovalDate":"","aiSummary":"The vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus through a live attenuated viral strain. Used for Prevention of yellow fever in travelers to endemic regions, Prevention of yellow fever in at-risk populations in endemic areas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}