{"id":"yellow-fever-17dd-vaccine","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Headache"},{"rate":"10-30","effect":"Myalgia"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Injection site reaction"},{"rate":"5-15","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The 17DD strain is a live attenuated yellow fever virus that replicates in vaccinated individuals without causing disease, triggering both humoral (antibody) and cell-mediated immune responses. This generates protective immunity against wild-type yellow fever virus infection. The vaccine has been used for decades and provides durable protection in the majority of vaccinees.","oneSentence":"The Yellow Fever 17DD vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus by using a live attenuated (weakened) viral strain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:33.896Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of yellow fever in endemic regions and travelers to yellow fever-endemic areas"}]},"trialDetails":[{"nctId":"NCT03725618","phase":"PHASE4","title":"Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 Months Old","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2018-11-01","conditions":"Yellow Fever","enrollment":1788},{"nctId":"NCT03338231","phase":"","title":"Clinical Study of Immunity Duration of Yellow Fever Vaccine in Military","status":"COMPLETED","sponsor":"The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)","startDate":"2017-03-27","conditions":"Yellow Fever Vaccine","enrollment":374}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Yellow Fever 17DD Vaccine","genericName":"Yellow Fever 17DD Vaccine","companyName":"Centers for Disease Control and Prevention","companyId":"centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"The Yellow Fever 17DD vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus by using a live attenuated (weakened) viral strain. Used for Prevention of yellow fever in endemic regions and travelers to yellow fever-endemic areas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}