{"id":"yaz-sh-t00186d","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Breast tenderness"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Mood changes"},{"rate":"5-10%","effect":"Vaginal bleeding irregularities"}]},"_chembl":{"chemblId":"CHEMBL117460","moleculeType":"Small molecule","molecularWeight":"604.69"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Drospirenone is a progestin that has anti-androgenic properties, which helps to prevent ovulation and also has some anti-inflammatory effects. Ethinyl estradiol is an estrogen that helps to regulate the menstrual cycle and prevent pregnancy.","oneSentence":"YAZ is a combination oral contraceptive that contains drospirenone and ethinyl estradiol, which work to prevent ovulation and pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:10.995Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of pregnancy"},{"name":"Treatment of moderate acne in women of childbearing potential"},{"name":"Treatment of hirsutism in women of childbearing potential"},{"name":"Treatment of symptoms of endometriosis"},{"name":"Treatment of symptoms of polycystic ovary syndrome (PCOS)"}]},"trialDetails":[{"nctId":"NCT00266032","phase":"PHASE3","title":"Study on Safety and Efficacy of an Oral Contraceptive in Long Cycles","status":"COMPLETED","sponsor":"Bayer","startDate":"2005-12","conditions":"Contraception","enrollment":1166},{"nctId":"NCT00569244","phase":"PHASE3","title":"SH T00186 in the Treatment of Primary Dysmenorrhea","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-12","conditions":"Primary Dysmenorrhea","enrollment":223},{"nctId":"NCT00567164","phase":"PHASE3","title":"Efficacy and Safety of Two Flexible Extended Regimens of BAY86-5300 (SH T00186D) in Comparison With the Conventional Regimen of YAZ","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-10","conditions":"Contraception, Ovulation Inhibition, Contraceptives, Oral","enrollment":1887},{"nctId":"NCT01253187","phase":"PHASE1","title":"Investigation of Bioequivalence of Ethinylestradiol (EE) and Drospirenone (DRSP) in Two Different Tablet Formulations: YAZ and YAZ + Levomefolate Calcium (Metafolin) & L-5-MTHF in Two Different Tablet Formulations: Levomefolate Calcium (Metafolin) and YAZ + Levomefolate Calcium (Metafolin)","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-10","conditions":"Contraception","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"YAZ (SH T00186D)","genericName":"YAZ (SH T00186D)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"YAZ is a combination oral contraceptive that contains drospirenone and ethinyl estradiol, which work to prevent ovulation and pregnancy. Used for Prevention of pregnancy, Treatment of moderate acne in women of childbearing potential, Treatment of hirsutism in women of childbearing potential.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}