{"id":"yasmin-ee30-drsp-bay86-5131","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Breast tenderness"},{"rate":"5-10%","effect":"Vaginal bleeding irregularities"},{"rate":"5-10%","effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The estrogen component, ethinyl estradiol, suppresses the release of gonadotropin-releasing hormone, which in turn inhibits the release of follicle-stimulating hormone and luteinizing hormone. The progestin component, drospirenone, has anti-androgenic and anti-mineralocorticoid effects, which contribute to its contraceptive efficacy.","oneSentence":"Yasmin is a combination oral contraceptive that works by inhibiting ovulation through the estrogen and progestin components.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:15.234Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dysmenorrhea"},{"name":"Acne"},{"name":"Hirsutism"},{"name":"Dysfunctional uterine bleeding"},{"name":"Emergency contraception"}]},"trialDetails":[{"nctId":"NCT01254292","phase":"PHASE3","title":"LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study","status":"COMPLETED","sponsor":"Bayer","startDate":"2011-01-06","conditions":"Contraception","enrollment":567},{"nctId":"NCT00923572","phase":"","title":"Yasmin Post Marketing Surveillance","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-12","conditions":"Contraception","enrollment":777},{"nctId":"NCT00988910","phase":"","title":"Effects of Drospirenone-containing or -Not Containing Combined Oral Contraceptives on General and Sexual Well-being","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-01","conditions":"Contraception","enrollment":632},{"nctId":"NCT01253174","phase":"PHASE1","title":"Investigation of Bioequivalence of Ethinylestradiol (EE) and Drospirenone (DRSP) in Two Different Tablet Formulations: Yasmin and Yasmin + Levomefolate Calcium (Metafolin) & L-5-MTHF in Two Different Tablet Formulations: Levomefolate Calcium (Metafolin) and Yasmin + Levomefolate Calcium (Metafolin)","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-08","conditions":"Contraception","enrollment":48},{"nctId":"NCT00905684","phase":"","title":"Effects of Counseling on the Continuation Rates and Compliance for Newly Prescribed Oral Contraceptives (Yasmin® or Any Other Oral Contraceptives (OC)","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-06","conditions":"Contraception","enrollment":5446}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Yasmin (EE30/DRSP, BAY86-5131)","genericName":"Yasmin (EE30/DRSP, BAY86-5131)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Yasmin is a combination oral contraceptive that works by inhibiting ovulation through the estrogen and progestin components. Used for Dysmenorrhea, Acne, Hirsutism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}