{"id":"xylometazoline-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Sneezing"},{"rate":null,"effect":"Rebound congestion (with prolonged use)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1256400","moleculeType":"Small molecule","molecularWeight":"280.84"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By stimulating alpha-1 adrenergic receptors on vascular smooth muscle in the nasal mucosa, xylometazoline induces vasoconstriction that decreases blood flow to nasal tissues and reduces swelling and congestion. This provides rapid symptomatic relief of nasal obstruction associated with colds, allergies, and sinusitis. The effect is topical and localized to the nasal cavity when administered as a nasal spray or solution.","oneSentence":"Xylometazoline is a selective alpha-1 adrenergic receptor agonist that causes vasoconstriction of nasal blood vessels, reducing nasal congestion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:40.386Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion due to common cold"},{"name":"Nasal congestion due to allergic rhinitis"},{"name":"Nasal congestion due to sinusitis"}]},"trialDetails":[{"nctId":"NCT05474924","phase":"PHASE4","title":"The Role of Budesonide Intrapolyp Injection in CRSwNP","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2022-08-01","conditions":"CRS, Polyp, Nasal","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zymelin"],"phase":"marketed","status":"active","brandName":"Xylometazoline 0,1%","genericName":"Xylometazoline 0,1%","companyName":"Rigshospitalet, Denmark","companyId":"rigshospitalet-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Xylometazoline 0.1% is a small molecule medication used to treat conditions such as chronic rhinosinusitis with nasal polyps, as indicated by clinical trials on ClinicalTrials.gov. It is a nasal decongestant, as suggested by its synonyms listed on ChEMBL, which include OTRIVINE and NEO-SYNEPHRINE II.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}