{"id":"xylitol-lactoperoxidase-lysozyme-lactoferrin","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Xylitol works by interfering with the ability of bacteria to adhere to and colonize surfaces, thereby preventing the formation of biofilms. Lactoperoxidase, Lysozyme, and Lactoferrin have direct antimicrobial effects, helping to eliminate or inhibit the growth of pathogens.","oneSentence":"Xylitol inhibits bacterial adhesion and biofilm formation, while Lactoperoxidase, Lysozyme, and Lactoferrin have antimicrobial properties.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:55:00.032Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of dental caries"}]},"trialDetails":[{"nctId":"NCT06984848","phase":"NA","title":"Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients","status":"NOT_YET_RECRUITING","sponsor":"ZAINAB MAT YUDIN","startDate":"2025-08-01","conditions":"Xerostomia, Geriatric","enrollment":100},{"nctId":"NCT05342272","phase":"PHASE3","title":"Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction","status":"COMPLETED","sponsor":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","startDate":"2017-09-22","conditions":"Xerostomia","enrollment":40},{"nctId":"NCT03663231","phase":"NA","title":"Duration of Effect of Biotene Spray in Patients With Dry Mouth","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2019-02-11","conditions":"Dry Mouth","enrollment":37}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Biotene® Oral Balance Gel"],"phase":"phase_3","status":"active","brandName":"Xylitol, Lactoperoxidase, Lysozyme, Lactoferrin","genericName":"Xylitol, Lactoperoxidase, Lysozyme, Lactoferrin","companyName":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","companyId":"azienda-socio-sanitaria-territoriale-degli-spedali-civili-di-brescia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Xylitol inhibits bacterial adhesion and biofilm formation, while Lactoperoxidase, Lysozyme, and Lactoferrin have antimicrobial properties. Used for Prevention of dental caries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}