{"id":"xoma-985","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Infusion-related reactions"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"IL-15 is a critical driver of natural killer (NK) cell and T-cell expansion and survival. By neutralizing IL-15, XOMA 985 modulates immune responses in conditions where excessive or dysregulated immune activation contributes to pathology. This mechanism is being explored in inflammatory and autoimmune conditions where IL-15 plays a pathogenic role.","oneSentence":"XOMA 985 is a monoclonal antibody that targets and inhibits IL-15, a key cytokine involved in immune cell activation and proliferation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:41:12.235Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory bowel disease (IBD)"}]},"trialDetails":[{"nctId":"NCT01556997","phase":"PHASE3","title":"Perindopril Amlodipine for the Treatment of Hypertension","status":"COMPLETED","sponsor":"Symplmed Pharmaceuticals LLC","startDate":"2012-02","conditions":"Essential Hypertension","enrollment":837}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"XOMA 985","genericName":"XOMA 985","companyName":"Symplmed Pharmaceuticals LLC","companyId":"symplmed-pharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"XOMA 985 is a monoclonal antibody that targets and inhibits IL-15, a key cytokine involved in immune cell activation and proliferation. Used for Inflammatory bowel disease (IBD).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}