{"id":"xiao-yao-san","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL4297822","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This classical herbal combination works by promoting the free flow of liver qi, strengthening spleen function, and harmonizing the body's energy systems according to traditional Chinese medicine theory. It is traditionally used to address stress-related symptoms, mood disturbance, and digestive complaints that arise from emotional constraint and constitutional weakness.","oneSentence":"Xiao-Yao-San is a traditional Chinese herbal formula that regulates liver qi stagnation and spleen deficiency to restore emotional and digestive balance.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:16:20.424Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver qi stagnation with spleen deficiency"},{"name":"Stress-related emotional and digestive symptoms"},{"name":"Premenstrual syndrome and menstrual irregularities"}]},"trialDetails":[{"nctId":"NCT07285707","phase":"NA","title":"Acupuncture and Chinese Herbal Medicine for Long COVID","status":"RECRUITING","sponsor":"Southern California University of Health Sciences","startDate":"2025-09-10","conditions":"Long COVID","enrollment":10},{"nctId":"NCT06417515","phase":"PHASE4","title":"The Potential Benefit of Xiao-Yao-San Treatment in Patients With Insomnia","status":"COMPLETED","sponsor":"Yu-Ching HSU","startDate":"2019-01-01","conditions":"Treatment","enrollment":19},{"nctId":"NCT04785261","phase":"PHASE2","title":"Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Disease","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2021-03-16","conditions":"Dry Eye Disease, Dry Eye Syndromes, Dry Eye","enrollment":60},{"nctId":"NCT04111341","phase":"PHASE2","title":"A Clinical Trial to Evaluate the Safety and Efficacy of Traditional Chinese Medicine in Sjögren's Syndrome.","status":"COMPLETED","sponsor":"Chung Shan Medical University","startDate":"2016-05-06","conditions":"Sjögren's Syndrome","enrollment":30},{"nctId":"NCT03838952","phase":"NA","title":"The Efficacy of Traditional Chinese Herbal Medicine for Dementia","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2019-02-11","conditions":"Dementia, Alzheimer Disease","enrollment":20},{"nctId":"NCT03018821","phase":"NA","title":"The Study of Two Different Chinese Traditional Medicine Treatment on Chronic Hepatitis B","status":"UNKNOWN","sponsor":"Xi'an Traditional Medicine Hospital","startDate":"2017-01","conditions":"Hepatitis B， Chronic","enrollment":250},{"nctId":"NCT02873234","phase":"","title":"A Study of Chinese Medicine Treating Depression","status":"UNKNOWN","sponsor":"The Third Affiliated Hospital of Beijing University of Chinese Medicine","startDate":"2016-06","conditions":"Depression","enrollment":4600}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"DRUG INEFFECTIVE"},{"count":1,"reaction":"INJECTION SITE SWELLING"},{"count":1,"reaction":"MIGRAINE"}],"_approvalHistory":[],"publicationCount":117,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Xiao-Yao-San","genericName":"Xiao-Yao-San","companyName":"Yu-Ching HSU","companyId":"yu-ching-hsu","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Xiao-Yao-San is a traditional Chinese herbal formula that regulates liver qi stagnation and spleen deficiency to restore emotional and digestive balance. Used for Liver qi stagnation with spleen deficiency, Stress-related emotional and digestive symptoms, Premenstrual syndrome and menstrual irregularities.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}