{"id":"xaracoll","safety":{"commonSideEffects":[{"rate":null,"effect":"Surgical site infection"},{"rate":null,"effect":"Seroma formation"},{"rate":null,"effect":"Hematoma"},{"rate":null,"effect":"Wound dehiscence"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":{"setId":"46da5733-c892-43a5-b826-1898a753f1c3","title":"XARACOLL (BUPIVACAINE HCL COLLAGEN-MATRIX) IMPLANT [INNOCOLL PHARMACEUTICALS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"XaraColl combines a native collagen matrix with chlorhexidine gluconate, a broad-spectrum antimicrobial agent. The collagen provides a hemostatic scaffold that promotes clotting and wound healing, while the chlorhexidine is released locally to reduce bacterial colonization and infection risk. The matrix is gradually absorbed and replaced by native tissue.","oneSentence":"XaraColl is a bioabsorbable collagen matrix that delivers chlorhexidine locally to promote hemostasis and reduce infection in surgical wounds.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:41:03.077Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and infection prevention in surgical wounds"},{"name":"Use as an adjunct to hemostasis during general, cardiac, and vascular surgery"}]},"trialDetails":[{"nctId":"NCT04785638","phase":"PHASE3","title":"An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries","status":"COMPLETED","sponsor":"Innocoll","startDate":"2021-04-14","conditions":"Pain, Postoperative, Hernia, Ventral, Abdominoplasty","enrollment":100},{"nctId":"NCT04785625","phase":"PHASE3","title":"Efficacy and Safety Study of Postsurgical Analgesia With INL-001 in Abdominoplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2021-04-29","conditions":"Pain, Postoperative, Abdominoplasty","enrollment":366},{"nctId":"NCT03262688","phase":"PHASE3","title":"Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair","status":"UNKNOWN","sponsor":"Innocoll","startDate":"2017-06-16","conditions":"Inguinal Hernia, Postoperative Pain","enrollment":159},{"nctId":"NCT02525133","phase":"PHASE3","title":"Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2015-09-05","conditions":"Pain, Postoperative","enrollment":319},{"nctId":"NCT02523599","phase":"PHASE3","title":"Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty","status":"COMPLETED","sponsor":"Innocoll","startDate":"2015-08","conditions":"Pain, Postoperative","enrollment":305},{"nctId":"NCT02232178","phase":"PHASE2","title":"Pharmacokinetics, Relative Bioavailability and Safety of Xaracoll Implant","status":"COMPLETED","sponsor":"Innocoll","startDate":"2014-10-20","conditions":"Hernioplasty","enrollment":64}],"_emaApprovals":[],"_faersSignals":[{"count":5,"reaction":"BLOODY DISCHARGE"},{"count":5,"reaction":"POST PROCEDURAL HAEMATOMA"},{"count":4,"reaction":"PROCEDURAL PAIN"},{"count":3,"reaction":"OFF LABEL USE"},{"count":3,"reaction":"SEROMA"},{"count":2,"reaction":"PLATELET DYSFUNCTION"},{"count":2,"reaction":"POSTOPERATIVE WOUND INFECTION"},{"count":2,"reaction":"WOUND ABSCESS"},{"count":1,"reaction":"INCISION SITE SWELLING"},{"count":1,"reaction":"INGUINAL HERNIA"}],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bupivacaine collagen implant"],"phase":"marketed","status":"active","brandName":"XaraColl","genericName":"XaraColl","companyName":"Innocoll","companyId":"innocoll","modality":"Small molecule","firstApprovalDate":"","aiSummary":"XaraColl is a bioabsorbable collagen matrix that delivers chlorhexidine locally to promote hemostasis and reduce infection in surgical wounds. Used for Hemostasis and infection prevention in surgical wounds, Use as an adjunct to hemostasis during general, cardiac, and vascular surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}