{"id":"xamiol-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or burning at application site"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Local skin atrophy (with prolonged use)"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcipotriene acts as a vitamin D receptor agonist, promoting differentiation and reducing proliferation of keratinocytes, while betamethasone dipropionate provides anti-inflammatory effects through glucocorticoid receptor activation. Together, these complementary mechanisms address both the hyperproliferation and inflammatory components of psoriatic plaques.","oneSentence":"Xamiol® Gel combines calcipotriene (a vitamin D analog) and betamethasone dipropionate (a corticosteroid) to reduce skin inflammation and normalize keratinocyte differentiation in psoriasis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:15.551Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque psoriasis (topical treatment)"}]},"trialDetails":[{"nctId":"NCT01195831","phase":"PHASE3","title":"Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-09","conditions":"Scalp Psoriasis","enrollment":244},{"nctId":"NCT01120223","phase":"PHASE2","title":"Safety and Efficacy of LEO 80185 Gel in Adolescent Subjects (Aged 12 to 17) With Scalp Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-05","conditions":"Scalp Psoriasis","enrollment":78},{"nctId":"NCT01083758","phase":"PHASE2","title":"Safety and Efficacy of LEO 80185 Topical Suspension in Adolescent Subjects (Aged 12 to 17) With Scalp Psoriasis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-04","conditions":"Scalp Psoriasis","enrollment":31},{"nctId":"NCT02533973","phase":"PHASE4","title":"Long-term Treatment of Scalp Psoriasis With Xamiol® Gel in a Large Adult Chinese Population","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-09","conditions":"Psoriasis Vulgaris","enrollment":951},{"nctId":"NCT01052467","phase":"","title":"Topical Treatment of Scalp Psoriasis With the Fixed Combination of Calcipotriol and Betamethason (Xamiol® Gel)","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-01","conditions":"Scalp Psoriasis","enrollment":724},{"nctId":"NCT01229098","phase":"PHASE2","title":"Effect of LEO 80185 Gel on the HPA Axis and Calcium Metabolism in Subjects With Extensive Psoriasis Vulgaris","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-10","conditions":"Psoriasis Vulgaris","enrollment":102},{"nctId":"NCT02636101","phase":"","title":"Xamiol®Gel in BODY Psoriasis: A One-year Non-interventional Study","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-01","conditions":"Psoriasis Vulgaris","enrollment":603},{"nctId":"NCT02004574","phase":"PHASE4","title":"Study for Treatment With Calcipotriol/Betamethasone Dipropionate Gel in Korean Patients With Psoriasis Vulgaris","status":"COMPLETED","sponsor":"Jooheung Lee","startDate":"2013-10","conditions":"Psoriasis Vulgaris","enrollment":201}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Xamiol® Gel","genericName":"Xamiol® Gel","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Xamiol Gel is a topical medication used to treat Scalp Psoriasis and Psoriasis Vulgaris, as indicated by ClinicalTrials.gov. The exact mechanism of action of Xamiol Gel is unknown, according to ChEMBL.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}