{"id":"wobenzym-plus","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions (rare)"},{"rate":null,"effect":"Mild digestive discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The product contains a blend of proteolytic enzymes (bromelain, papain, trypsin, chymotrypsin) and other cofactors that work to digest inflammatory proteins and immune complexes in the body. These enzymes are believed to modulate the inflammatory response and enhance immune function by promoting the clearance of circulating immune complexes and reducing pro-inflammatory mediators. The mechanism is thought to support the body's natural anti-inflammatory and immune-regulating processes.","oneSentence":"Wobenzym plus is a proteolytic enzyme combination that reduces inflammation and supports immune modulation through enzymatic breakdown of inflammatory mediators and immune complexes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:16:16.900Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and degenerative joint conditions"},{"name":"Post-operative swelling and inflammation"},{"name":"Immune support and inflammation management"}]},"trialDetails":[{"nctId":"NCT05038410","phase":"NA","title":"Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment With Bromelain, Trypsin and Rutoside Versus Placebo in Subjects With OsTeoarthritis","status":"COMPLETED","sponsor":"Mucos Pharma GmbH & Co. KG","startDate":"2021-04-30","conditions":"Osteoarthritis","enrollment":40},{"nctId":"NCT03470337","phase":"PHASE3","title":"Phlogenzym® in Patients With Acute Thrombophlebitis - Efficacy and Tolerance","status":"COMPLETED","sponsor":"Mucos Pharma GmbH & Co. KG","startDate":"1996-09","conditions":"Thrombophlebitis Leg","enrollment":100},{"nctId":"NCT00974428","phase":"PHASE2, PHASE3","title":"Multi-Center Study Evaluating the Efficacy of Wobenzym(R)N in Treating Knee Osteoarthritis","status":"WITHDRAWN","sponsor":"Atrium Innovations","startDate":"2009-10","conditions":"Knee Osteoarthritis","enrollment":""},{"nctId":"NCT01845558","phase":"PHASE4","title":"Effects of Wobenzym® Plus in Healthy, Sportive People After Eccentric Exercise","status":"COMPLETED","sponsor":"Mucos Pharma GmbH & Co. KG","startDate":"2013-02","conditions":"Muscle Injury, Muscle Soreness, Exercise Induced Muscle Damage","enrollment":69}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["manufacturing authorisation number DE_BE_01_MIA_2012_0034/5373/1 - MUCOS/4"],"phase":"marketed","status":"active","brandName":"Wobenzym® plus","genericName":"Wobenzym® plus","companyName":"Mucos Pharma GmbH & Co. KG","companyId":"mucos-pharma-gmbh-co-kg","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Wobenzym plus is a proteolytic enzyme combination that reduces inflammation and supports immune modulation through enzymatic breakdown of inflammatory mediators and immune complexes. Used for Inflammatory and degenerative joint conditions, Post-operative swelling and inflammation, Immune support and inflammation management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}