{"id":"withdrawal-of-furosemide","safety":{"commonSideEffects":[{"rate":null,"effect":"Fluid retention / edema rebound"},{"rate":null,"effect":"Hyperkalemia (if potassium supplementation ongoing)"},{"rate":null,"effect":"Hypertension rebound"},{"rate":null,"effect":"Worsening heart failure (if indicated for diuresis)"}]},"_chembl":{"chemblId":"CHEMBL35","moleculeType":"Small molecule","molecularWeight":"330.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide is a loop diuretic that inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, promoting sodium, potassium, and water excretion. Withdrawal reverses this mechanism, reducing urinary losses and allowing fluid retention and electrolyte repletion. This is a clinical management strategy rather than a pharmacological intervention.","oneSentence":"Withdrawal of furosemide allows restoration of normal fluid and electrolyte balance by discontinuing loop diuretic activity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:16:10.079Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Management of furosemide-induced adverse effects (hypokalemia, dehydration, electrolyte imbalance)"},{"name":"Clinical de-escalation in heart failure or edema management"}]},"trialDetails":[{"nctId":"NCT04572867","phase":"NA","title":"Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure","status":"WITHDRAWN","sponsor":"Ramona Gelzer Bell","startDate":"2021-06-08","conditions":"Heart Failure, Congestive Heart Failure, Decompensated Heart Failure","enrollment":""},{"nctId":"NCT02892799","phase":"NA","title":"Non-invasive Fluid Management","status":"UNKNOWN","sponsor":"Intermountain Health Care, Inc.","startDate":"2015-11-12","conditions":"Respiratory Distress Syndrome, Adult","enrollment":100},{"nctId":"NCT03274427","phase":"PHASE3","title":"Treatment of Intermediate-stage Hepatocellular Carcinoma","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Zhengzhou University","startDate":"2017-07-18","conditions":"HCC","enrollment":300},{"nctId":"NCT03278444","phase":"PHASE3","title":"Treatment of Advanced Hepatocellular Carcinoma","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Zhengzhou University","startDate":"2017-07-18","conditions":"HCC","enrollment":300},{"nctId":"NCT01815892","phase":"PHASE4","title":"The Use of Furosemide in Patients on Dialysis","status":"UNKNOWN","sponsor":"Unity Health Toronto","startDate":"2015-05","conditions":"End Stage Renal Disease","enrollment":51},{"nctId":"NCT02689180","phase":"PHASE3","title":"Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2015-05","conditions":"Heart Failure","enrollment":230}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lasix"],"phase":"marketed","status":"active","brandName":"Withdrawal of furosemide","genericName":"Withdrawal of furosemide","companyName":"Unity Health Toronto","companyId":"unity-health-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Withdrawal of furosemide allows restoration of normal fluid and electrolyte balance by discontinuing loop diuretic activity. Used for Management of furosemide-induced adverse effects (hypokalemia, dehydration, electrolyte imbalance), Clinical de-escalation in heart failure or edema management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}