{"id":"welbutrin-xl","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Insomnia"},{"rate":"17-25","effect":"Dry mouth"},{"rate":"8-13","effect":"Nausea"},{"rate":"26","effect":"Headache"},{"rate":"6-11","effect":"Dizziness"},{"rate":"0.4","effect":"Seizures"}]},"_chembl":{"chemblId":"CHEMBL3545328","moleculeType":"Small molecule","molecularWeight":"444.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By inhibiting the reuptake of norepinephrine and dopamine, Wellbutrin XL allows these neurotransmitters to remain active longer in the synaptic space, enhancing their signaling. This mechanism differs from selective serotonin reuptake inhibitors (SSRIs) and is thought to improve mood, motivation, and energy. The extended-release formulation provides sustained drug levels throughout the day.","oneSentence":"Wellbutrin XL is a norepinephrine-dopamine reuptake inhibitor (NDRI) that increases levels of norepinephrine and dopamine in the brain by blocking their reuptake at the neuronal synapse.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:09.427Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Seasonal affective disorder"},{"name":"Smoking cessation (off-label use)"}]},"trialDetails":[{"nctId":"NCT02562430","phase":"PHASE4","title":"Neurobiological Underpinnings of Placebo Response in Depression","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2016-08","conditions":"Depression","enrollment":73}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Buproprion XL"],"phase":"marketed","status":"active","brandName":"Welbutrin XL","genericName":"Welbutrin XL","companyName":"Massachusetts General Hospital","companyId":"massachusetts-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Wellbutrin XL is a norepinephrine-dopamine reuptake inhibitor (NDRI) that increases levels of norepinephrine and dopamine in the brain by blocking their reuptake at the neuronal synapse. Used for Major depressive disorder, Seasonal affective disorder, Smoking cessation (off-label use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}