{"id":"weight-loss","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL4594468","moleculeType":"Unknown"},"_dailymed":{"setId":"fd0b6097-e886-410c-acf8-fff475677af8","title":"WEIGHT LOSS SUPPORT PLUS ADRENAL (GLYCYRRHIZA GLABRA, FOENICULUM VULGARE, AMMONIUM BROMATUM, FUCUS VESICULOSUS, LECITHIN (DERIVED FROM EGG), ARALIA QUINQUEFOLIA, CAPSICUM ANNUUM, GALIUM APARINE, HYPOTHALAMUS SUIS, KALI BICHROMICUM, LAC DEFLORATUM (NSPC), PHYTOLACCA DECANDRA, THYROIDINUM (BOVINE), GLANDULA SUPRARENALIS (BOVINE), PITUITARUM POSTERIUM (BOVINE), ANTIMONIUM CRUDUM, ARGENTUM METALLICUM, CALCAREA CARBONICA, ADRENALINUM, PHOSPHORUS, ADRENOCORTICOTROPHIN) SPRAY [CAROLINAS WEIGHT LOSS INSTITUTE]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Weight loss can be achieved through multiple mechanisms including GLP-1 receptor agonism, sympathomimetic stimulation, lipase inhibition, or other metabolic pathways. Without a specific drug name or molecular target, a precise mechanism cannot be determined. The University of Texas Southwestern Medical Center may be researching novel weight loss therapeutics, but the mechanism is not specified.","oneSentence":"This is a generic category ('weight loss') rather than a specific drug, so no single mechanism applies.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T02:57:40.731Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Weight loss / Obesity management"}]},"trialDetails":[{"nctId":"NCT07349641","phase":"PHASE2","title":"A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer","status":"NOT_YET_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2026-07-06","conditions":"Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma","enrollment":55},{"nctId":"NCT06857929","phase":"NA","title":"\"Improving Health and Reducing Chronic Disease Risk in Middle-Aged Adults Through Nutrition\"","status":"RECRUITING","sponsor":"IMDEA Food","startDate":"2026-03-01","conditions":"Metabolic Syndrome, Obesity Prevention, Obesity and Overweight","enrollment":106},{"nctId":"NCT07478653","phase":"NA","title":"MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease","status":"NOT_YET_RECRUITING","sponsor":"Oelisoa Andriankaja","startDate":"2026-05-01","conditions":"Obesity, Dental Care for Children","enrollment":50},{"nctId":"NCT06751589","phase":"EARLY_PHASE1","title":"A Study of a Weight Loss Intervention in People With Endometrial Cancer","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2024-12-19","conditions":"Endometrial Cancer","enrollment":36},{"nctId":"NCT07437976","phase":"","title":"A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Environmental Health Sciences (NIEHS)","startDate":"2026-04-01","conditions":"Obesity","enrollment":400},{"nctId":"NCT06023537","phase":"NA","title":"Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity","status":"COMPLETED","sponsor":"Williams College","startDate":"2023-07-11","conditions":"Obesity, Weight Loss","enrollment":119},{"nctId":"NCT01927783","phase":"","title":"Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention","status":"RECRUITING","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2014-02-08","conditions":"Cardiovascular Disease, Obesity","enrollment":200},{"nctId":"NCT07498985","phase":"NA","title":"Exercise for the Treatment of Cancer-Related Sarcopenia","status":"NOT_YET_RECRUITING","sponsor":"State University of Londrina","startDate":"2026-04-01","conditions":"Cancer, Sarcopenia","enrollment":78},{"nctId":"NCT05562427","phase":"NA","title":"Program for Fully Understanding Eating and Lifestyle Change (FUEL)","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Miriam Hospital","startDate":"2022-10-31","conditions":"Obesity","enrollment":150},{"nctId":"NCT07495696","phase":"","title":"Possibilities of Recording Changes in Various Health Parameters by Measuring Bioimpedance With the mBCA 555 During the Use of Products From the L112 Product Range","status":"COMPLETED","sponsor":"Certmedica International GmbH","startDate":"2025-04-15","conditions":"Overweight","enrollment":41},{"nctId":"NCT06945419","phase":"PHASE1","title":"A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2025-04-23","conditions":"Healthy, Overweight, Obesity","enrollment":216},{"nctId":"NCT07457437","phase":"NA","title":"Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment","status":"RECRUITING","sponsor":"University of Exeter","startDate":"2026-04-01","conditions":"Muscle Mass and Strength, Obesity & Overweight, Physical Function","enrollment":60},{"nctId":"NCT07495904","phase":"NA","title":"Effect of GLP-1 Receptor Agonists on Body Composition in Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance","status":"NOT_YET_RECRUITING","sponsor":"Hellenic Mediterranean University","startDate":"2026-03-30","conditions":"Obesity","enrollment":130},{"nctId":"NCT06692335","phase":"NA","title":"HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2025-02-06","conditions":"Uterine Fibroids (UF)","enrollment":112},{"nctId":"NCT04599478","phase":"PHASE2, PHASE3","title":"Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Yale University","startDate":"2021-06-29","conditions":"Loss-of-control Eating, Obesity/Overweight","enrollment":160},{"nctId":"NCT04036331","phase":"NA","title":"Dyad Plus Effectiveness/Feasibility","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2021-07-30","conditions":"Weight Loss, Pediatric Obesity, Overweight Adolescents","enrollment":90},{"nctId":"NCT07361874","phase":"NA","title":"IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2026-03-05","conditions":"Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's","enrollment":75},{"nctId":"NCT06930495","phase":"","title":"The Effect of Adiposity on Muscle and Microvascular Function in HFpEF","status":"ENROLLING_BY_INVITATION","sponsor":"University of Texas Southwestern Medical Center","startDate":"2024-12-10","conditions":"Heart Failure With Preserved Ejection Fraction (HFPEF)","enrollment":95},{"nctId":"NCT02858336","phase":"NA","title":"CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study)","status":"COMPLETED","sponsor":"National Institute of Environmental Health Sciences (NIEHS)","startDate":"2017-01-12","conditions":"Hormones","enrollment":38},{"nctId":"NCT05788744","phase":"NA","title":"Implementing ctDNA and Circular DNA in Patients With Localized Pancreatic Cancer","status":"RECRUITING","sponsor":"Copenhagen University Hospital at Herlev","startDate":"2023-01-01","conditions":"Resectable Pancreatic Cancer","enrollment":1000},{"nctId":"NCT07149428","phase":"","title":"Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)","status":"NOT_YET_RECRUITING","sponsor":"National Institute on Deafness and Other Communication Disorders (NIDCD)","startDate":"2026-04-01","conditions":"Respiratory Tract Infection, Smell Disorder, Influenza","enrollment":80},{"nctId":"NCT07446998","phase":"PHASE2","title":"Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss","status":"RECRUITING","sponsor":"Veru Inc.","startDate":"2026-03","conditions":"Obesity & Overweight, Mobility Disability, HOMA-IR","enrollment":200},{"nctId":"NCT07000539","phase":"NA","title":"Indocyanine Green Fluorescence Angiography (ICG-FA) in Revisional Bariatric Surgery","status":"RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-05-06","conditions":"Obesity, Bariatric Surgery","enrollment":108},{"nctId":"NCT04868032","phase":"NA","title":"Gaining Optimism After Weight Loss Surgery (GOALS) II","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2022-07-01","conditions":"Bariatric Surgery","enrollment":58},{"nctId":"NCT07492212","phase":"NA","title":"Comparison of Blood Loss Between Cemented and Uncemented Femoral Stems in Anterior Total Hip Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Clinique du Pré","startDate":"2026-04-15","conditions":"Total Hip Arthroplasty (THA)","enrollment":86},{"nctId":"NCT06047548","phase":"PHASE3","title":"A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2023-09-20","conditions":"Overweight, Obesity","enrollment":441},{"nctId":"NCT06630663","phase":"NA","title":"A Wearable Device and AI-Supported Diet and Exercise Intervention","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2025-08-10","conditions":"Obesity and Obesity-related Medical Conditions","enrollment":120},{"nctId":"NCT05870982","phase":"NA","title":"Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2023-07-11","conditions":"Overweight and Obesity","enrollment":162},{"nctId":"NCT06854185","phase":"NA","title":"Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2025-02-05","conditions":"Metabolic Dysfunction Associated Steatotic Liver Disease, Overweight (BMI &gt; 25), Metabolic Syndrome","enrollment":50},{"nctId":"NCT00739362","phase":"PHASE2","title":"Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2009-01-19","conditions":"Electric Stimulation Therapy, Obesity, Weight Loss","enrollment":148},{"nctId":"NCT06989437","phase":"PHASE2, PHASE3","title":"A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue","status":"RECRUITING","sponsor":"Pfizer","startDate":"2025-10-03","conditions":"Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma","enrollment":982},{"nctId":"NCT05942326","phase":"NA","title":"Sleep Goal-focused Online Access to Lifestyle Support","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2023-09-21","conditions":"Weight Loss, Weight, Body","enrollment":40},{"nctId":"NCT05925959","phase":"NA","title":"Preoperative Weight Loss for Open Abdominal Wall Reconstruction","status":"RECRUITING","sponsor":"Benjamin T. Miller","startDate":"2023-06-19","conditions":"Abdominal Wall Hernia","enrollment":258},{"nctId":"NCT07462663","phase":"","title":"SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer","status":"NOT_YET_RECRUITING","sponsor":"Hospital Universitari de Bellvitge","startDate":"2026-05","conditions":"Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I","enrollment":82},{"nctId":"NCT05408494","phase":"NA","title":"Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program","status":"ACTIVE_NOT_RECRUITING","sponsor":"Drexel University","startDate":"2023-09-01","conditions":"Obesity, Weight Loss","enrollment":228},{"nctId":"NCT07301437","phase":"PHASE4","title":"RWS of of Liraglutide Alone and in Combination With Orlistat for Weight Loss in Overweight/Obese Patients.","status":"NOT_YET_RECRUITING","sponsor":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","startDate":"2026-05-01","conditions":"Overweight and Obese Adults","enrollment":120},{"nctId":"NCT05656807","phase":"NA","title":"Evaluation of Child Care Staff Weight Management Program","status":"RECRUITING","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2023-01-18","conditions":"Obesity","enrollment":924},{"nctId":"NCT05539716","phase":"NA","title":"Metabolism and Sleep Apnea Treatment","status":"RECRUITING","sponsor":"University of Miami","startDate":"2022-05-20","conditions":"Obstructive Sleep Apnea, Fat Disorder","enrollment":100},{"nctId":"NCT07393360","phase":"NA","title":"Effect of a Food for Special Medical Purposes on Muscle Mass Preservation During GLP-1 RAs Weight Loss Treatment","status":"RECRUITING","sponsor":"Pharmanutra S.p.a.","startDate":"2025-12-11","conditions":"Obesity & Overweight","enrollment":144},{"nctId":"NCT07487090","phase":"PHASE2","title":"Fasted vs. Fed State Exercise","status":"RECRUITING","sponsor":"Arkansas Colleges of Health Education","startDate":"2026-01-05","conditions":"Obesity, Exercise, Weight Loss","enrollment":40},{"nctId":"NCT07428187","phase":"NA","title":"Snacking Effects on the Brain Response to Foods and Satiety During Dieting","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2026-03-05","conditions":"Overweight/Obesity","enrollment":70},{"nctId":"NCT07486765","phase":"NA","title":"FundoRing Roux-en-Y Gastric Bypass Versus FundoRing One Anastomosis Gastric Bypass","status":"COMPLETED","sponsor":"The Society of Bariatric and Metabolic Surgeons of Kazakhstan","startDate":"2024-07-04","conditions":"Obesity, Roux-en-y Anastomosis Site, Reflux Gastritis","enrollment":200},{"nctId":"NCT07398404","phase":"PHASE1, PHASE2","title":"A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients","status":"NOT_YET_RECRUITING","sponsor":"Yale University","startDate":"2026-07-01","conditions":"Obesity, Smoking Cessation, Bariatric Surgery Patients","enrollment":64},{"nctId":"NCT00687115","phase":"PHASE2","title":"Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2008-09-18","conditions":"Obesity, Diet Therapy, Weight Loss","enrollment":83},{"nctId":"NCT06477900","phase":"NA","title":"Impact of SMS Reminder on Weight Loss, as Part of a Health Pathway in Patients With Prediabetes (PREDIABCOACH)","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de la Réunion","startDate":"2025-01-22","conditions":"PreDiabetes","enrollment":300},{"nctId":"NCT07481630","phase":"PHASE3","title":"A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain","status":"NOT_YET_RECRUITING","sponsor":"Novo Nordisk A/S","startDate":"2026-04-13","conditions":"Obesity, Knee Osteoarthritis (OA)","enrollment":400},{"nctId":"NCT04986631","phase":"EARLY_PHASE1","title":"Pharmacokinetics and Pharmacodynamics of Topiramate for Weight Loss in Youth: PHARMATOP","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Minnesota","startDate":"2022-04-04","conditions":"Obesity, Childhood","enrollment":62},{"nctId":"NCT07483801","phase":"PHASE4","title":"DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies","status":"NOT_YET_RECRUITING","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2026-03","conditions":"Cardiovascular Diseases","enrollment":112},{"nctId":"NCT06667999","phase":"PHASE4","title":"The Intensive Care Platform Trial","status":"RECRUITING","sponsor":"Anders Perner","startDate":"2025-06-26","conditions":"Intensive Care Patients, Intensive Care Unit Patients, Critical Illness","enrollment":10000},{"nctId":"NCT07224087","phase":"PHASE1","title":"Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients","status":"RECRUITING","sponsor":"Yale University","startDate":"2026-03-02","conditions":"Obesity, Smoking Cessation, Bariatric Surgery Patients","enrollment":20},{"nctId":"NCT06066528","phase":"PHASE3","title":"A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight","status":"ACTIVE_NOT_RECRUITING","sponsor":"Boehringer Ingelheim","startDate":"2023-11-27","conditions":"Obesity, Diabetes Mellitus, Type 2","enrollment":755},{"nctId":"NCT06914219","phase":"NA","title":"Implementing an Interdisciplinary Eating Disorder Screening and Treatment Program for Post-Bariatric Surgery Patients in Nova Scotia","status":"RECRUITING","sponsor":"Aaron Keshen","startDate":"2026-03-04","conditions":"Bariatric Surgery Patients, Disordered Eating Behaviors","enrollment":250},{"nctId":"NCT07190794","phase":"","title":"RESCUE: Discontinuation of GLP-1","status":"RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2025-12-17","conditions":"Obesity","enrollment":150},{"nctId":"NCT07481305","phase":"NA","title":"Lifestyle Change Implementation Research Network at PRC at UMass Chan","status":"NOT_YET_RECRUITING","sponsor":"University of Massachusetts, Worcester","startDate":"2026-04-15","conditions":"GLP - 1","enrollment":220},{"nctId":"NCT07406568","phase":"NA","title":"Pilot Trial of the Move Healthier Group","status":"NOT_YET_RECRUITING","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2026-05-01","conditions":"Obesity, Overweight","enrollment":12},{"nctId":"NCT05653258","phase":"PHASE2, PHASE3","title":"Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects","status":"RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2023-10-17","conditions":"Obesity, Healthy Lifestyle","enrollment":160},{"nctId":"NCT07281937","phase":"PHASE2","title":"A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities","status":"ACTIVE_NOT_RECRUITING","sponsor":"Verdiva Bio Dev Limited","startDate":"2025-11-25","conditions":"Obesity, Overweight","enrollment":206},{"nctId":"NCT07480109","phase":"NA","title":"Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)","status":"NOT_YET_RECRUITING","sponsor":"University of Texas at Austin","startDate":"2026-04-01","conditions":"Obesity, Women (Between 30 to 60 Years Old)","enrollment":75},{"nctId":"NCT07120828","phase":"PHASE4","title":"The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity","status":"COMPLETED","sponsor":"Erbil Polytechnic University","startDate":"2025-07-15","conditions":"Type 2 Diabetes, Obese Diabetics, Obese Patients (BMI ≥ 30 kg/m²)","enrollment":260},{"nctId":"NCT07207148","phase":"","title":"People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2025-11-15","conditions":"Multiple Sclerosis","enrollment":100},{"nctId":"NCT03091725","phase":"NA","title":"Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB","status":"ACTIVE_NOT_RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2017-04-25","conditions":"Obesity","enrollment":30},{"nctId":"NCT06998238","phase":"NA","title":"Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2024-01-07","conditions":"Overweight and Obesity, Hyperandrogenemia, Insulin Resistance","enrollment":8},{"nctId":"NCT07478497","phase":"NA","title":"30 Day Insulin Balance Metabolic Health Optimization Protocol","status":"RECRUITING","sponsor":"Efforia, Inc","startDate":"2025-10-21","conditions":"Insulin","enrollment":100},{"nctId":"NCT03713775","phase":"NA","title":"LOSE-AF: Can Weight Loss Help Patients With Atrial Fibrillation?","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2018-11-14","conditions":"Atrial Fibrillation, Overweight and Obesity","enrollment":119},{"nctId":"NCT07475507","phase":"NA","title":"Effect of PEEK and Titanium Framework Reinforcement on Marginal Bone Loss Around Implants Supporting a Fixed All-on-four Prosthesis in Completely Edentulous Mandibles","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-08-01","conditions":"Prosthodontics, Implants, Dental, Prosthesis","enrollment":20},{"nctId":"NCT07118904","phase":"NA","title":"Effect of Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses in Combat Athletes","status":"RECRUITING","sponsor":"Abant Izzet Baysal University","startDate":"2025-08-18","conditions":"Dehydration, Weight Loss, Weight Cycling","enrollment":12},{"nctId":"NCT07473492","phase":"","title":"Assessment of Malnutrition in Hospitalized Patients: a Quasi Study","status":"NOT_YET_RECRUITING","sponsor":"AlFayhaa General Hospital","startDate":"2026-04-01","conditions":"COPD , Neurology , ICU, Alzheimer, Alzheimer s Disease","enrollment":300},{"nctId":"NCT07396805","phase":"NA","title":"Trial of Food Is Medicine Approaches for Obesity Treatment in Adults With Food Insecurity","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2026-03-13","conditions":"Obesity & Overweight","enrollment":300},{"nctId":"NCT07237750","phase":"NA","title":"iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) vs Optimized Lifestyle Intervention for Weight Loss","status":"RECRUITING","sponsor":"Liu Yan","startDate":"2026-03-01","conditions":"Overweight and/or Obesity, Metabolic Syndrome, Nonalcoholic Fatty Liver Disease","enrollment":216},{"nctId":"NCT07219706","phase":"NA","title":"Dietary Fiber and Time Restricted Eating","status":"RECRUITING","sponsor":"University of Oklahoma","startDate":"2026-12-10","conditions":"Diet Habits, Cancer Prevention","enrollment":90},{"nctId":"NCT06309992","phase":"PHASE3","title":"A Study to Test Whether Survodutide Helps People Living With Obesity or Overweight and With a Confirmed or Presumed Liver Disease Called Non-alcoholic Steatohepatitis (NASH) to Reduce Liver Fat and to Lose Weight","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2024-04-02","conditions":"Obesity, Non-Alcoholic SteatoHepatitis (NASH)","enrollment":218},{"nctId":"NCT06894498","phase":"","title":"Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss","status":"RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2026-03","conditions":"Obesity and Obesity-related Medical Conditions, Weight Loss","enrollment":100},{"nctId":"NCT01351753","phase":"PHASE2","title":"Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity","status":"TERMINATED","sponsor":"University of Iowa","startDate":"2011-03","conditions":"Obesity, Metabolic Syndrome X","enrollment":128},{"nctId":"NCT07467447","phase":"PHASE2","title":"Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight","status":"RECRUITING","sponsor":"Hudson Biotech","startDate":"2026-02-15","conditions":"Obesity","enrollment":300},{"nctId":"NCT07464223","phase":"","title":"MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"yu li，MD","startDate":"2024-09-01","conditions":"Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis","enrollment":50},{"nctId":"NCT07400107","phase":"PHASE3","title":"AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight","status":"NOT_YET_RECRUITING","sponsor":"Novo Nordisk A/S","startDate":"2026-05-20","conditions":"Obesity, Overweight, Diabetes Mellitus, Type 2","enrollment":1000},{"nctId":"NCT07467512","phase":"NA","title":"Exercise for an Aging Liver (EXALIVER)","status":"NOT_YET_RECRUITING","sponsor":"Consorcio Centro de Investigación Biomédica en Red (CIBER)","startDate":"2026-03","conditions":"MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis/NASH","enrollment":40},{"nctId":"NCT07062094","phase":"","title":"Safety and Effectiveness of Orbera365™ Intragastric Balloon System","status":"NOT_YET_RECRUITING","sponsor":"Boston Scientific Corporation","startDate":"2026-03","conditions":"Obesity","enrollment":200},{"nctId":"NCT06066515","phase":"PHASE3","title":"A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2023-11-25","conditions":"Obesity","enrollment":726},{"nctId":"NCT07463417","phase":"NA","title":"Evaluating the SWW Method Dietary Intervention for HbA1c and Weight Management as a Preventative Intervention in Women","status":"COMPLETED","sponsor":"Sarah Wragge Wellness","startDate":"2024-04-01","conditions":"Metabolic Syndrome, Obesity & Overweight, Blood Glucose Monitoring","enrollment":85},{"nctId":"NCT04662879","phase":"NA","title":"Early Detection Initiative for Pancreatic Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pancreatic Cancer Action Network","startDate":"2021-10-14","conditions":"Hyperglycemia, Diabetes Mellitus, Pancreas Ductal Adenocarcinoma","enrollment":8869},{"nctId":"NCT07213466","phase":"PHASE4","title":"Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-01-19","conditions":"Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder","enrollment":100},{"nctId":"NCT05649137","phase":"PHASE3","title":"A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2023-01-04","conditions":"Obesity, Diabetes Mellitus, Type 2","enrollment":512},{"nctId":"NCT05326477","phase":"NA","title":"Predictors of Behavioral Obesity Treatment Outcomes","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2023-05-26","conditions":"Obesity","enrollment":230},{"nctId":"NCT07465341","phase":"NA","title":"Michigan Weight Navigation Program (MiWeigh) Study","status":"NOT_YET_RECRUITING","sponsor":"University of Michigan","startDate":"2026-03","conditions":"Obesity","enrollment":500},{"nctId":"NCT07465094","phase":"NA","title":"Workplace Health Promotion \"So Healthy, Lose 99\" Weight Loss Activity","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2025-03-31","conditions":"Obesity","enrollment":518},{"nctId":"NCT05926024","phase":"","title":"Long-Term Follow-Up in Women With Early Breast Cancer Three Years of More Post Primary Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2023-01-06","conditions":"Breast Cancer","enrollment":253},{"nctId":"NCT07292441","phase":"PHASE3","title":"Extension Study of the Phase 3 Clinical Study of GZR18 Injection for Weight Loss","status":"RECRUITING","sponsor":"Gan & Lee Pharmaceuticals.","startDate":"2026-01-22","conditions":"Overweight or Obesity","enrollment":500},{"nctId":"NCT04337619","phase":"NA","title":"Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss","status":"COMPLETED","sponsor":"Drexel University","startDate":"2019-08-15","conditions":"Obesity, Weight Loss","enrollment":276},{"nctId":"NCT07465172","phase":"NA","title":"GDF-15 and Its Relationship With Treatment-related ADverse Events in Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"Breast Cancer Trials, Australia and New Zealand","startDate":"2026-03","conditions":"Breast Cancer","enrollment":150},{"nctId":"NCT05985486","phase":"NA","title":"Brain Outcomes With Lifestyle Change in Down Syndrome","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2024-10-22","conditions":"Down Syndrome, Alzheimer Disease, Obesity","enrollment":81},{"nctId":"NCT07461610","phase":"","title":"Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-03","conditions":"Morbid Obesity","enrollment":50},{"nctId":"NCT07461740","phase":"NA","title":"Effect of a Mindful Eating Education Program on Mindful Eating, Hedonic Hunger, and Anthropometric Measures in Obese Individuals With High Hedonic Hunger","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2023-06-30","conditions":"Hedonic Hunger, Mindful Eating Intervention, Obesity & Overweight","enrollment":82},{"nctId":"NCT05598840","phase":"NA","title":"Efficacy of a Mobile Application to Help in Weight Loss Before Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital Universitari de Bellvitge","startDate":"2022-10-18","conditions":"Morbid Obesity, Weight Loss","enrollment":142},{"nctId":"NCT07461870","phase":"NA","title":"The Mediterranean Diet Based on Local Foods for Obese Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Indonesia University","startDate":"2025-12-09","conditions":"Obese Subjects","enrollment":54},{"nctId":"NCT07460544","phase":"NA","title":"Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks","status":"NOT_YET_RECRUITING","sponsor":"University of Washington","startDate":"2026-05","conditions":"Overweight/Obesity, Puberty, Health Behavior","enrollment":240},{"nctId":"NCT07456332","phase":"NA","title":"Effect on Body Weight Reduction of a Behavioral Intervention on Lifestyle Using a Digital Nutritional Program in People Living With HIV and Metabolic Dysfunction-associated Steatotic Liver Disease","status":"ENROLLING_BY_INVITATION","sponsor":"Hospital Universitari de Bellvitge","startDate":"2025-04-23","conditions":"Metabolic Dysfunction-Associated Steatotic Liver Disease, People Living With HIV, Life Style","enrollment":116},{"nctId":"NCT07461701","phase":"NA","title":"Study of 15% Versus 30% Velocity Loss Thresholds During Bodyweight Squats and Their Effects on Strength and Endurance in Young Women","status":"RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2026-02-22","conditions":"Lower-Limb Strength, Muscular Endurance, Velocity-Based Resistance Training","enrollment":52},{"nctId":"NCT05076513","phase":"EARLY_PHASE1","title":"Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nader Sanai","startDate":"2021-10-29","conditions":"Glioblastoma, Glioblastoma Multiforme, Glioma","enrollment":42},{"nctId":"NCT02774759","phase":"NA","title":"Feasibility of the NEXT Steps Weight Loss Intervention +/- Resistance Training for Endometrial Cancer Survivors: Effect on Lean Mass & Biomarkers","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2016-10-17","conditions":"Malignant Neoplasms of Female Genital Organs","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":131471,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Weight loss","genericName":"Weight loss","companyName":"University of Texas Southwestern Medical Center","companyId":"university-of-texas-southwestern-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a generic category ('weight loss') rather than a specific drug, so no single mechanism applies. Used for Weight loss / Obesity management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":10,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}