{"id":"warfarin-vs-asa","safety":{"commonSideEffects":[{"rate":"1-3%","effect":"Bleeding (major)"},{"rate":"5-15%","effect":"Bleeding (minor)"},{"rate":"1-2%","effect":"Gastrointestinal bleeding"},{"rate":"0.5-1%","effect":"Intracranial hemorrhage"},{"rate":"5-10%","effect":"Dyspepsia (aspirin)"}]},"_chembl":{"chemblId":"CHEMBL1464","moleculeType":"Small molecule","molecularWeight":"308.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Warfarin inhibits vitamin K-dependent clotting factors (II, VII, IX, X) to reduce thrombus formation, while aspirin irreversibly inhibits platelet cyclooxygenase to prevent platelet aggregation. The comparison evaluates their relative efficacy and safety in preventing stroke and other thromboembolic events.","oneSentence":"This is a comparative analysis of two anticoagulant/antiplatelet agents: warfarin (a vitamin K antagonist) and aspirin (an antiplatelet agent), used to prevent thrombotic events.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:04.973Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Stroke prevention in atrial fibrillation"},{"name":"Thromboembolism prevention post-myocardial infarction"},{"name":"Venous thromboembolism prophylaxis and treatment"}]},"trialDetails":[{"nctId":"NCT07456085","phase":"PHASE3","title":"Rivaroxaban vs Warfarin in Patients With Mechanical Heart Valves","status":"ENROLLING_BY_INVITATION","sponsor":"Rawalpindi Institute of Cardiology","startDate":"2025-11-13","conditions":"Valvular Heart Disease Patients","enrollment":60},{"nctId":"NCT03807921","phase":"PHASE4","title":"Anticoagulation for Aortic Bioprosthesis (ANTIPRO)","status":"COMPLETED","sponsor":"Instituto Nacional de Cirugia Cardiaca, Uruguay","startDate":"2019-01-01","conditions":"Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency","enrollment":140},{"nctId":"NCT02164864","phase":"PHASE3","title":"Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2014-07-22","conditions":"Atrial Fibrillation, Percutaneous Coronary Intervention","enrollment":2725},{"nctId":"NCT00524862","phase":"NA","title":"Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death","status":"TERMINATED","sponsor":"Unity Health Toronto","startDate":"2007-10","conditions":"Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction","enrollment":5000},{"nctId":"NCT00182104","phase":"PHASE4","title":"International Multi Centre Randomized Clinical Trial Of Anticoagulation In Children Following Fontan Procedures","status":"COMPLETED","sponsor":"Hamilton Health Sciences Corporation","startDate":"1998-08","conditions":"Heart Defect, Triscupid Atresia","enrollment":111}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Warfarin vs ASA","genericName":"Warfarin vs ASA","companyName":"Hamilton Health Sciences Corporation","companyId":"hamilton-health-sciences-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Warfarin is used to treat conditions such as heart defects, aortic valve disease, and aortic valve insufficiency, as seen in clinical trials on ClinicalTrials.gov. Aspirin, on the other hand, is also studied in clinical trials on ClinicalTrials.gov for similar conditions, but its exact indications and comparisons to Warfarin are not specified in the provided facts.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}