{"id":"warfarin-natrium","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Bleeding"},{"rate":"5-10%","effect":"Nosebleeds"},{"rate":"5-10%","effect":"Bruising"},{"rate":"1-5%","effect":"Gastrointestinal bleeding"},{"rate":"<1%","effect":"Hemorrhagic stroke"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by blocking the action of vitamin K, a necessary component in the production of clotting factors II, VII, IX, and X. This leads to a decrease in the production of these clotting factors, resulting in a reduction of blood clot formation.","oneSentence":"Warfarin-Natrium is an anticoagulant that inhibits vitamin K-dependent clotting factors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:59.222Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation"},{"name":"Treatment and prevention of deep vein thrombosis and pulmonary embolism"}]},"trialDetails":[{"nctId":"NCT00895505","phase":"PHASE3","title":"D-Dimer Guided Oral Anticoagulant Treatment (OAT)","status":"UNKNOWN","sponsor":"University Hospital, Bonn","startDate":"2008-02","conditions":"Deep Venous Thrombosis","enrollment":300}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"BACK PAIN"},{"count":1,"reaction":"CHRONIC OBSTRUCTIVE PULMONARY DISEASE"},{"count":1,"reaction":"DRY GANGRENE"},{"count":1,"reaction":"GASTRIC DISORDER"},{"count":1,"reaction":"HEPATIC ENZYME INCREASED"},{"count":1,"reaction":"HERPES ZOSTER"},{"count":1,"reaction":"PERIPHERAL ARTERY THROMBOSIS"},{"count":1,"reaction":"SYNCOPE"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Warfarin-Natrium","genericName":"Warfarin-Natrium","companyName":"University Hospital, Bonn","companyId":"university-hospital-bonn","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Warfarin-Natrium is an anticoagulant that inhibits vitamin K-dependent clotting factors. Used for Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, Treatment and prevention of deep vein thrombosis and pulmonary embolism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}