{"id":"vitamin-k2","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":{"chemblId":"CHEMBL5314971","moleculeType":"Small molecule","molecularWeight":"580.90"},"_dailymed":{"setId":"10b7a6d1-36d6-47f1-9fed-699f04cf9edd","title":"YYUX ORGANIC LIQUID VITAMIN D3 PLUS K2 DROPS (CHOLECALCIFEROL, MENAQUINONE 7) SOLUTION/ DROPS [YYUX INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin K2 (menaquinone) is an essential cofactor for the enzyme gamma-glutamyl carboxylase, which catalyzes the post-translational carboxylation of glutamic acid residues in bone proteins (osteocalcin, matrix Gla protein) and vascular proteins. This carboxylation is required for these proteins to bind calcium and exert their physiological effects on bone metabolism and vascular calcification prevention.","oneSentence":"Vitamin K2 acts as a cofactor for gamma-carboxylation of bone and vascular proteins, enabling their biological activity in bone mineralization and cardiovascular health.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:57:15.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis and bone health maintenance"},{"name":"Vascular calcification prevention"}]},"trialDetails":[{"nctId":"NCT06817512","phase":"NA","title":"Ischemic Stroke Nutrition Intervention Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Harbin Medical University","startDate":"2025-03-23","conditions":"Ischemic Stroke","enrollment":190},{"nctId":"NCT05259046","phase":"NA","title":"The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone 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