{"id":"vitamin-e-400-unt","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding (at high doses)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin E (alpha-tocopherol) is a chain-breaking antioxidant that donates electrons to free radicals, preventing lipid peroxidation in cell membranes and reducing oxidative stress. It works synergistically with other antioxidant systems to maintain cellular integrity and reduce inflammation associated with oxidative damage.","oneSentence":"Vitamin E acts as a fat-soluble antioxidant that neutralizes free radicals and protects cell membranes from oxidative damage.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:15:27.891Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin E deficiency"},{"name":"Antioxidant supplementation for general health maintenance"}]},"trialDetails":[{"nctId":"NCT03557229","phase":"PHASE3","title":"Clinical Trial of Antioxidant Therapy in Patients With Septic Shock","status":"UNKNOWN","sponsor":"American British Cowdray Medical Center","startDate":"2018-07-23","conditions":"Oxidative Stress, Septic Shock","enrollment":131},{"nctId":"NCT03358524","phase":"PHASE4","title":"Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2017-09-28","conditions":"Obesity, Adolescent, Oxidative Stress","enrollment":69}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vitamin E"],"phase":"marketed","status":"active","brandName":"Vitamin E 400 UNT","genericName":"Vitamin E 400 UNT","companyName":"American British Cowdray Medical Center","companyId":"american-british-cowdray-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin E 400 UNT has been studied in clinical trials for conditions including obesity, oxidative stress, and septic shock. It has been investigated as a supplement to potentially affect free radicals and fat levels in obese adolescents.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}