{"id":"vitamin-e","rwe":[],"_fda":{"id":"253d03be-e068-1bdf-e063-6294a90a6e50","set_id":"03963e9b-f7b4-f947-e063-6394a90ad004","openfda":{"unii":["UCN889409V"],"route":["TOPICAL"],"spl_id":["253d03be-e068-1bdf-e063-6294a90a6e50"],"brand_name":["Dove"],"spl_set_id":["03963e9b-f7b4-f947-e063-6394a90ad004"],"package_ndc":["64942-2170-1"],"product_ndc":["64942-2170"],"generic_name":["VITAMIN E AND KUKUI NUT OIL SOOTHING POST-SHAVE 48H ANTIPERSPIRANT DEODORANT"],"product_type":["HUMAN OTC DRUG"],"substance_name":["ALUMINUM SESQUICHLOROHYDRATE"],"manufacturer_name":["Conopco Inc. d/b/a/ Unilever"],"application_number":["M019"],"is_original_packager":[true]},"purpose":["Purpose antiperspirant"],"version":"2","warnings":["Warnings • For external use only. • Do not use on broken skin . • Ask a doctor before use if you have kidney disease. • Stop use if rash or irritation occurs."],"questions":["Questions? Call 1-800-761-3683"],"description":["SHEA MOISTURE RAW VITAMIN E & KUKUI NUT OIL POST-SHAVE 48H ANTIPERSPIRANT DEODORANT - aluminum sesquichlorohydrate stick"],"effective_time":"20241024","active_ingredient":["Drug Facts Active ingredient Aluminum Sesquichlorohydrate (12.2)"],"inactive_ingredient":["Inactive ingredients Water (Aqua), Synthetic Wax, Cyclopentasiloxane, Glycerin, C12-15 Alkyl Benzoate, Niacinamide, Calcium Chloride, Fragrance (Parfum), Cetyl PEG/PPG-10/1 Dimethicone, Glycine, Helianthus Annuus (Sunflower) Seed Oil, Butyrospermum Parkii (Shea) Butter, Aleurites Moluccanus Seed Oil, Hydroxystearic Acid, Alpha-Isomethyl Ionone, Benzyl Alcohol, Benzyl Salicylate. Coumarin, Limonene, Linalool"],"indications_and_usage":["Uses reduces underarm wetness"],"dosage_and_administration":["Directions apply to underarms only"],"spl_product_data_elements":["Dove Vitamin E and Kukui Nut Oil Soothing Post-Shave 48h Antiperspirant Deodorant LINALOOL, (+/-)- BENZYL SALICYLATE GLYCERIN CETYL PEG/PPG-10/1 DIMETHICONE (HLB 4) GLYCINE SHEA BUTTER KUKUI NUT OIL 12-HYDROXYSTEARIC ACID ISOMETHYL-.ALPHA.-IONONE ALKYL (C12-15) BENZOATE BENZYL ALCOHOL SUNFLOWER OIL CYCLOMETHICONE 5 CALCIUM CHLORIDE WATER SYNTHETIC WAX (1200 MW) ALUMINUM SESQUICHLOROHYDRATE ALUMINUM SESQUICHLOROHYDRATE LIMONENE, (+)- COUMARIN"],"keep_out_of_reach_of_children":["• Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["Packaging Shea Moisture Soothing AP Deo"]},"tags":[{"label":"Vitamin E","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Glutathione S-transferase P","category":"target"},{"label":"GSTP1","category":"gene"},{"label":"TTPA","category":"gene"},{"label":"A11HA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Vitamin E deficiency","category":"indication"},{"label":"Hospira","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Antioxidants","category":"pharmacology"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"drugInteractions":[{"url":"/drug/warfarin","drug":"warfarin","action":"Monitor closely","effect":"May interact with Warfarin","source":"DrugCentral","drugSlug":"warfarin"}]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=VITAMIN E","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:03:08.437189+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Vitamin E","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T03:03:16.124317+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:03:14.860560+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=VITAMIN E","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:03:15.063176+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:03:07.296057+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:03:07.296091+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3989727/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:03:15.771952+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M019","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:03:07.296097+00:00"}},"allNames":"m.v.i. pediatric","offLabel":[],"synonyms":["tocopherol (vit E)","Vitamin E","Tocofer 400"],"timeline":[{"date":"1953-02-20","type":"positive","source":"DrugCentral","milestone":"FDA approval (Hospira)"}],"aiSummary":"M.V.I. Pediatric (Vitamin E) is a small molecule drug developed by HOSPIRA, currently owned by the same company. It targets glutathione S-transferase P and belongs to the vitamin E class. Originally approved by the FDA in 1953, it is indicated for the treatment of vitamin E deficiency. As a patented product, its commercial status is proprietary. Key safety considerations include potential interactions with other medications.","brandName":"M.V.I. 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Pediatric functions by donating electrons to free radicals, thereby neutralizing them and preventing oxidative stress, which is mediated by glutathione S-transferase P."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Cyanocobalamin","title":"Cyanocobalamin","extract":"Cyanocobalamin is a form of vitamin B12 used to treat and prevent vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is given by mouth, by injection into a muscle, or as a nasal spray."},"commercial":{"launchDate":"1953","_launchSource":"DrugCentral (FDA 1953-02-20, HOSPIRA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3613","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=VITAMIN%20E","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=VITAMIN 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