{"id":"vitamin-d3-plus-dapagliflozin","safety":{"commonSideEffects":[{"rate":"null","effect":"Increased risk of diabetic ketoacidosis"},{"rate":"5-10%","effect":"Genital mycotic infections"},{"rate":"null","effect":"Increased risk of acute kidney injury"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Vitamin D3 binds to the vitamin D receptor (VDR), influencing gene expression and calcium homeostasis. Dapagliflozin blocks the sodium-glucose cotransporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and promoting urinary glucose excretion.","oneSentence":"Vitamin D3 acts as a hormone receptor agonist, while Dapagliflozin inhibits the SGLT2 transporter.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:43.234Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes"},{"name":"Chronic kidney disease"}]},"trialDetails":[{"nctId":"NCT06690723","phase":"PHASE3","title":"Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea","status":"COMPLETED","sponsor":"University Malaysia Sarawak","startDate":"2022-06-08","conditions":"Obstructive Sleep Apnea","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Vitamin D3 plus Dapagliflozin","genericName":"Vitamin D3 plus Dapagliflozin","companyName":"University Malaysia Sarawak","companyId":"university-malaysia-sarawak","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin D3 acts as a hormone receptor agonist, while Dapagliflozin inhibits the SGLT2 transporter. Used for Type 2 diabetes, Chronic kidney disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}