{"id":"vitamin-d3-cholecalciferol","_fda":{"id":"05e2ef7e-9af2-4189-9fba-5d104f606b19","set_id":"4c86b348-5808-4d6d-b283-00ab37557fd7","openfda":{"nui":["M0022797","N0000175952","N0000185508","N0000175629","N0000184306","M0000728","M0022788","N0000175950"],"unii":["5HOC10FSIC","Y538U8K055","M4I0D6VV5M","O3B55K4YKI","E934B3V59H","1C6V77QF41","1DP6Y6B65Z","P776JQ4R2F","0E53J927NA","42Z2K6ZL8P","723JX6CXY5","7OV03QG267","2E32821G6I","QX10HYY4QV","VP2CN2G7Y8","39981FM375","MN18OTN73W","91D9GV0Z28","4JS0838828","81G40H8B0T"],"route":["ORAL"],"spl_id":["05e2ef7e-9af2-4189-9fba-5d104f606b19"],"brand_name":["Bone Liquescence"],"spl_set_id":["4c86b348-5808-4d6d-b283-00ab37557fd7"],"package_ndc":["83027-0157-1"],"product_ndc":["83027-0157"],"generic_name":["TARAXACUM OFFICINALE, TRIFOLIUM PRATENSE, CALCAREA MURIATICA, EQUISETUM ARVENSE, JUGLANS NIGRA, SESAME OIL, CALCAREA SULPHURICA, HEPAR (BOVINE), KIDNEY (BOVINE), MEDULLA OSSIS SUIS, MENADIONE, THYROIDINUM (BOVINE), VITAMIN A, VITAMIN D3 (CHOLECALCIFEROL) , CALCAREA PHOSPHORICA, CALCAREA CARBONICA, CALCAREA FLUORICA MANGANUM METALLICUM, NICCOLUM METALLICUM, MAGNESIA CARBONICA"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Vitamin D [CS]","Allergens [CS]","Vitamin A [CS]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]"],"substance_name":["BEEF KIDNEY","BLACK WALNUT HUSK","CALCIUM CHLORIDE","CALCIUM FLUORIDE","CALCIUM SULFATE ANHYDROUS","CHOLECALCIFEROL","EQUISETUM ARVENSE TOP","HEPARIN, BOVINE","MAGNESIUM CARBONATE","MANGANESE","MENADIONE","NICKEL","OYSTER SHELL CALCIUM CARBONATE, CRUDE","SESAME OIL","SUS SCROFA BONE MARROW","TARAXACUM OFFICINALE","THYROID, BOVINE","TRIBASIC CALCIUM PHOSPHATE","TRIFOLIUM PRATENSE FLOWER","VITAMIN A"],"pharm_class_epc":["Vitamin D [EPC]","Standardized Chemical Allergen [EPC]","Vitamin A [EPC]"],"manufacturer_name":["Nutritional Specialties, Inc."],"is_original_packager":[true]},"purpose":["PURPOSE: Calcarea Carbonica – Back Discomfort, Bone Pain, Lameness, and Support of Joints and Bones,† Calcarea Fluorica – Bone Spurs, and Support of Bones,† Calcarea Muriatica – Support of Bones,† Calcarea Phosphorica – Bone Trauma, Fractures, Growing Pains, Slow Dentition, and Support of Bones,† Calcarea Sulphurica – Joint Pains, Swelling of Phalanges of Fingers, Weariness of Knees After Walking, and Support of Bones,† Equisetum Arvense – Support of Collagen and Bones,† Hepar (Liver) – Support of Liver,† Juglans Nigra – Support of Bones,† Kidney – Support of Kidneys,† Magnesia Carbonica – Support of Bones,† Manganum Metallicum – Joint Pain, Swollen Joints and Bones, and Support of Joints and Bones,† Medulla Ossis Suis – Support of Bone Marrow,† Menadione – Support of Bones,† Niccolum Metallicum – Support of Bones,† Sesame Oil – Aids in Healing and Support of Bones,† Taraxacum Officinale -Knee Pain, Joint Pains, and Tenderness of Limbs,† Thyroidinum – Support of Thyroid,† Trifolium Pratense – Support of Blood and Bones,† Vitamin A – Support of Bones,† Vitamin D3 (Cholecalciferol) – Supports Calcium and Phosphorus Absorption for Bone Health† †Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"version":"1","warnings":["WARNINGS: If pregnant or breast-feeding, ask a health professional before use. In case of overdose, get medical help or contact a Poison Control Center right away. If condition worsens, seek medical attention. KEEP OUT OF REACH OF CHILDREN Do not use if tamper evident seal is broken or missing. Store in a cool place after opening."],"questions":["QUESTIONS: MANUFACTURED EXCLUSIVELY FOR NUTRITIONAL SPECIALTIES, INC. PO BOX 97227 PITTSBURG, PA 15229 www.phpltd.com 1-800-245-1313"],"effective_time":"20251125","active_ingredient":["ACTIVE INGREDIENTS: (in each teaspoon) Calcarea Carbonica 9X, 12X, Calcarea Fluorica 12X, Calcarea Muriatica 4X, Calcarea Phosphorica 9X, Calcarea Sulphurica 5X, Equisetum Arvense 4X, Hepar (Liver) 6X, Juglans Nigra 4X, Kidney 6X, Magnesia Carbonica 12X, Manganum Metallicum 12X, Medulla Ossis Suis 6X, Menadione 6X, Niccolum Metallicum 12X, Sesame Oil 4X, Taraxacum Officinale 3X, Thyroidinum 6X, Trifolium Pratense 3X, Vitamin A 6X, Vitamin D3 (Cholecalciferol) 6X."],"inactive_ingredient":["INACTIVE INGREDIENTS: Alcohol USP 20%, Purified Water USP."],"indications_and_usage":["USE: Provides potentized homeo-nutritional support of the bones. †Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"dosage_and_administration":["DIRECTIONS: • Adults: 1 to 2 teaspoons, one to two times daily. Children under twelve one half adult dosage. • Consult a physician for use in children under 12 years of age."],"spl_product_data_elements":["Bone Liquescence Taraxacum Officinale, Trifolium Pratense, Calcarea Muriatica, Equisetum Arvense, Juglans Nigra, Sesame Oil, Calcarea Sulphurica, Hepar (Bovine), Kidney (Bovine), Medulla Ossis Suis, Menadione, Thyroidinum (Bovine), Vitamin A, Vitamin D3 (Cholecalciferol) , Calcarea Phosphorica, Calcarea Carbonica, Calcarea Fluorica Manganum Metallicum, Niccolum Metallicum, Magnesia Carbonica TARAXACUM OFFICINALE TARAXACUM OFFICINALE TRIFOLIUM PRATENSE FLOWER TRIFOLIUM PRATENSE (CLOVER) FLOWER CALCIUM CHLORIDE CALCIUM CATION EQUISETUM ARVENSE TOP EQUISETUM ARVENSE TOP BLACK WALNUT HUSK BLACK WALNUT HUSK SESAME OIL SESAME OIL CALCIUM SULFATE ANHYDROUS CALCIUM CATION HEPARIN, BOVINE HEPARIN, BOVINE BEEF KIDNEY BEEF KIDNEY SUS SCROFA BONE MARROW SUS SCROFA BONE MARROW MENADIONE MENADIONE THYROID, BOVINE THYROID, BOVINE VITAMIN A VITAMIN A CHOLECALCIFEROL CHOLECALCIFEROL TRIBASIC CALCIUM PHOSPHATE CALCIUM CATION OYSTER SHELL CALCIUM CARBONATE, CRUDE OYSTER SHELL CALCIUM CARBONATE, CRUDE CALCIUM FLUORIDE FLUORIDE ION MANGANESE MANGANESE NICKEL NICKEL MAGNESIUM CARBONATE CARBONATE ION WATER ALCOHOL"],"keep_out_of_reach_of_children":["KEEP OUT OF REACH OF CHILDREN: In case of overdose, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["PACKAGE LABEL DISPLAY: Professional Health Products HOMEOPATHIC NDC 83027-0157-1 BONE LIQUESCENCE 4 FL. OZ (120 ml) BONE LIQUESCENCE"]},"safety":{"boxedWarnings":[]},"_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Vitamin D3 cholecalciferol)","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T05:10:40.457184+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T05:11:01.511421+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T05:10:48.419368+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Vitamin D3 cholecalciferol)","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T05:10:48.714643+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:10:39.180512+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:10:39.180546+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:10:56.748174+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:10:39.180550+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Vitamin D receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:10:49.830471+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1042/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:10:49.499162+00:00"}},"_dailymed":{"setId":"4c86b348-5808-4d6d-b283-00ab37557fd7","title":"BONE LIQUESCENCE (TARAXACUM OFFICINALE, TRIFOLIUM PRATENSE, CALCAREA MURIATICA, EQUISETUM ARVENSE, JUGLANS NIGRA, SESAME OIL, CALCAREA SULPHURICA, HEPAR (BOVINE), KIDNEY (BOVINE), MEDULLA OSSIS SUIS, MENADIONE, THYROIDINUM (BOVINE), VITAMIN A, VITAMIN D3 (CHOLECALCIFEROL) , CALCAREA PHOSPHORICA, CALCAREA CARBONICA, CALCAREA FLUORICA MANGANUM METALLICUM, NICCOLUM METALLICUM, MAGNESIA CARBONICA) LIQUID [NUTRITIONAL SPECIALTIES, INC.]"},"aiSummary":"Vitamin D3 (cholecalciferol), marketed by the Abramson Cancer Center at Penn Medicine, serves as a homeo-nutritional support for bone health. A key strength is the protection provided by a composition patent expiring in 2028. The primary risk is the lack of significant revenue data, which may impact market valuation and investment interest.","mechanism":{"drugClass":"Vitamin D [EPC]"},"_scrapedAt":"2026-03-28T00:15:32.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T05:11:01.511515+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"id":"vitamin-d3-cholecalciferol-homeo-nutritional-support-of-b","name":"Homeo-nutritional support of bones","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":""}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[{"count":10,"reaction":"HEADACHE"},{"count":6,"reaction":"DYSPNOEA"},{"count":6,"reaction":"FATIGUE"},{"count":6,"reaction":"NAUSEA"},{"count":4,"reaction":"ANXIETY"},{"count":4,"reaction":"ASTHENIA"},{"count":4,"reaction":"BACK PAIN"},{"count":4,"reaction":"DIZZINESS"},{"count":4,"reaction":"PNEUMONIA"},{"count":4,"reaction":"URINARY TRACT INFECTION"}],"administration":{"route":"Oral"},"crossReferences":{"chemblId":"CHEMBL1042"},"_approvalHistory":[],"publicationCount":189,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Natures Made Vitamin D3","Cholecalciferol","Vitamin D3","Placebo, inert white powder","Vitamin D3 Matching Placebo"],"phase":"marketed","status":"active","brandName":"Vitamin D3 cholecalciferol)","genericName":"Vitamin D3 cholecalciferol)","companyName":"Abramson Cancer Center at Penn Medicine","companyId":"abramson-cancer-center-at-penn-medicine","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T05:11:01.511515+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}