{"id":"vitamin-b3","safety":{"commonSideEffects":[{"rate":"50-80","effect":"Flushing and skin redness"},{"rate":"10-20","effect":"Pruritus"},{"rate":"10-15","effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":"null","effect":"Hyperglycemia"},{"rate":"null","effect":"Hyperuricemia"},{"rate":"null","effect":"Hepatotoxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1140","moleculeType":"Small molecule","molecularWeight":"122.13"},"_dailymed":{"setId":"a7382d84-1d5f-4d09-962f-b26f265af65e","title":"B COMPLEX LIQUESCENCE (CHOLINUM (CHOLINE), INOSITOL (VITAMIN B8), FOLIC ACID (VITAMIN B9), PANTOTHENIC ACID (CALCIUM PANTOTHENATE, VITAMIN B5), THIAMINUM HYDROCHLORICUM (VITAMIN B1), HEART (BOVINE), HEPAR (BOVINE), METHYLCOBALAMIN (VITAMIN B12), NICOTINAMIDUM (VITAMIN B3), PABA (PARA AMINOBENZOIC ACID VITAMIN B10), PYRIDOXINUM HYDROCHLORICUM (VITAMIN B6), BIOTIN (VITAMIN B7), HORDEUM VULGARE, RIBOFLAVINUM (VITAMIN B2), TORULA CEREVISIAE) LIQUID [NUTRITIONAL SPECIALTIES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Niacin is converted to nicotinamide adenine dinucleotide (NAD+) and NADP+, which serve as critical coenzymes in oxidation-reduction reactions throughout cellular metabolism. These cofactors are required for glycolysis, the citric acid cycle, and the electron transport chain, enabling ATP production and supporting numerous biosynthetic pathways. Additionally, NAD+-dependent enzymes regulate DNA repair, stress responses, and cellular signaling.","oneSentence":"Vitamin B3 (niacin) acts as a precursor to NAD+ cofactors essential for cellular energy metabolism and DNA repair.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:37.432Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Niacin deficiency (pellagra)"},{"name":"Hyperlipidemia (elevated cholesterol and triglycerides)"},{"name":"Cardiovascular disease prevention"}]},"trialDetails":[{"nctId":"NCT01303341","phase":"PHASE1","title":"Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2011-02-18","conditions":"Advanced Malignant Solid Neoplasm, Recurrent Melanoma, Refractory Malignant Solid Neoplasm","enrollment":35},{"nctId":"NCT06044935","phase":"NA","title":"Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2024-01-08","conditions":"Overweight, Obesity","enrollment":100},{"nctId":"NCT01861314","phase":"PHASE1","title":"Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2013-07-03","conditions":"Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, Recurrent Adult Acute Myeloid Leukemia","enrollment":15},{"nctId":"NCT04430517","phase":"EARLY_PHASE1","title":"Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mclean Hospital","startDate":"2022-03-02","conditions":"Mild Cognitive Impairment, Mild Alzheimer Disease","enrollment":50},{"nctId":"NCT02298348","phase":"PHASE1","title":"Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory Neuroblastoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"New Approaches to Neuroblastoma Therapy Consortium","startDate":"2015-10-08","conditions":"Neuroblastoma","enrollment":18},{"nctId":"NCT06587945","phase":"PHASE4","title":"Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment","status":"RECRUITING","sponsor":"Center for Eye Research Australia","startDate":"2025-09-19","conditions":"Retinal Detachment","enrollment":144},{"nctId":"NCT07463651","phase":"PHASE3","title":"MRD-guided Maintenance Post-HCT: Gilteritini vs Sorafenib","status":"RECRUITING","sponsor":"The First Affiliated Hospital of Soochow University","startDate":"2026-05-01","conditions":"Acute Myeloid Leukemia (AML), FLT3-ITD Mutation, Allogeneic Hematopoietic Cell Transplantation (HCT)","enrollment":594},{"nctId":"NCT03298451","phase":"PHASE3","title":"Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2017-10-11","conditions":"Hepatocellular Carcinoma","enrollment":1324},{"nctId":"NCT05702398","phase":"EARLY_PHASE1","title":"Pilot Trial of Supplemental Vitamin A and Nicotinamide","status":"RECRUITING","sponsor":"Rhode Island Hospital","startDate":"2023-04-01","conditions":"Skin Cancer, Kidney Transplant Recipients","enrollment":30},{"nctId":"NCT04614714","phase":"PHASE2, PHASE3","title":"Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants","status":"NOT_YET_RECRUITING","sponsor":"University of California, Davis","startDate":"2026-04-01","conditions":"Preterm Birth, Inadequate Milk Production","enrollment":40},{"nctId":"NCT06309485","phase":"PHASE2","title":"Phase 2 Study of WGI-0301 for Advanced HCC","status":"RECRUITING","sponsor":"Zhejiang Haichang Biotech Co., Ltd.","startDate":"2024-07-31","conditions":"Advanced Hepatocellular Carcinoma (HCC)","enrollment":60},{"nctId":"NCT04720716","phase":"PHASE3","title":"A Study to Compare the Effectiveness and Safety of IBI310 Combined With Sintilimab Versus Sorafenib in the First-line Treatment of Advanced HCC","status":"COMPLETED","sponsor":"Innovent Biologics (Suzhou) Co. 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