{"id":"vitamin-b1-ratiopharm","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Local injection site reactions (if parenteral)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thiamine is converted to thiamine pyrophosphate (TPP), which serves as an essential cofactor for several key enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase and transketolase. It is critical for energy production in cells and proper functioning of the nervous system, particularly in nerve impulse transmission and myelin formation.","oneSentence":"Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:15:28.267Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thiamine (Vitamin B1) deficiency"},{"name":"Wernicke-Korsakoff syndrome"},{"name":"Beriberi"},{"name":"Thiamine deficiency-related neurological conditions"}]},"trialDetails":[{"nctId":"NCT01524315","phase":"PHASE4","title":"Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2012-02-01","conditions":"Heart Failure, Acidosis, Lactic, Thiamine Deficiency","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vitamin B1-ratiopharm®"],"phase":"marketed","status":"active","brandName":"Vitamin B1-ratiopharm","genericName":"Vitamin B1-ratiopharm","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function. Used for Thiamine (Vitamin B1) deficiency, Wernicke-Korsakoff syndrome, Beriberi.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}