{"id":"vitamin-a","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypervitaminosis A (toxicity at excessive doses)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Skin irritation (topical formulations)"},{"rate":null,"effect":"Teratogenicity (at high doses in pregnancy)"}]},"_chembl":{"chemblId":"CHEMBL986","moleculeType":"Small molecule","molecularWeight":"286.46"},"patents":[],"_fixedAt":"2026-03-30T12:46:55.251001","_dailymed":{"setId":"ef79cadb-c553-4af1-9a53-6ea1ab26b4bb","title":"MULTIVITAMIN WITH FLUORIDE (.ALPHA.-TOCOPHEROL ACETATE, DL-, ASCORBIC ACID, CYANOCOBALAMIN, FOLIC ACID, NIACIN, PYRIDOXINE, RIBOFLAVIN, SODIUM FLUORIDE, THIAMINE MONONITRATE, VITAMIN A AND VITAMIN D) TABLET, CHEWABLE [BRYANT RANCH PREPACK]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin A (retinol) is converted to its active forms, retinal and retinoic acid, which bind to retinoid X receptors (RXR) and retinoic acid receptors (RAR) in cell nuclei. These receptor-ligand complexes modulate transcription of genes critical for visual cycle function, immune cell development and function, epithelial cell differentiation, and antioxidant defense. Vitamin A deficiency impairs these processes, particularly affecting vision and immune competence.","oneSentence":"Vitamin A acts as a ligand for nuclear retinoid receptors, regulating gene expression involved in vision, immune function, and cellular differentiation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:03.583Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin A deficiency"},{"name":"Measles (adjunctive therapy in deficient populations)"},{"name":"Xerophthalmia and night blindness"},{"name":"Support of immune function"}]},"_fixedFields":["sideEffects","generics(6)","patents(0)","modality→Small Molecule"],"patentStatus":"Off-patent — no active Orange Book patents","trialDetails":[{"nctId":"NCT07348120","phase":"NA","title":"Efficacy and Safety of Millet Seed Extract in Telogen Effluvium Treatment","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2025-05-01","conditions":"Telogen Effluvium","enrollment":60},{"nctId":"NCT07494045","phase":"PHASE2","title":"Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants","status":"NOT_YET_RECRUITING","sponsor":"OPKO Health, Inc.","startDate":"2026-06","conditions":"CKD Stage 3, CKD Stage 4, Secondary Hyperparathyroidism","enrollment":40},{"nctId":"NCT05855824","phase":"NA","title":"Toddler Biomarker of Nutrition Study","status":"NOT_YET_RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2026-06-01","conditions":"Pediatric Nutrition, Nutrition, Healthy","enrollment":150},{"nctId":"NCT06172296","phase":"PHASE3","title":"Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2024-04-19","conditions":"Ganglioneuroblastoma, Nodular, Neuroblastoma","enrollment":478},{"nctId":"NCT01711554","phase":"PHASE1","title":"Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2013-02-04","conditions":"Recurrent Neuroblastoma, Refractory Neuroblastoma","enrollment":27},{"nctId":"NCT07495592","phase":"NA","title":"The Acute Effects of Onnit Alpha Brain on Cognition and Mood States","status":"NOT_YET_RECRUITING","sponsor":"Applied Science & Performance Institute","startDate":"2026-04-16","conditions":"Cognitive, Mood and Cognitive Performance, Sleep Deprivation","enrollment":34},{"nctId":"NCT00001309","phase":"PHASE1","title":"The Body's Affect on Vitamin C","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"1997-01-23","conditions":"Healthy Volunteers","enrollment":23},{"nctId":"NCT07496281","phase":"PHASE4","title":"OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation","status":"NOT_YET_RECRUITING","sponsor":"Ewha Womans University Mokdong Hospital","startDate":"2027-03-01","conditions":"Atrial Fibrillation (AF), Coronary Artery Disease, Drug-eluting Stent","enrollment":2},{"nctId":"NCT02905591","phase":"PHASE2","title":"A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Joseph J. 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