{"id":"viscum-album","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, induration)"},{"rate":null,"effect":"Fever and chills"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL5483015","moleculeType":"Small molecule","molecularWeight":"197.84"},"_dailymed":{"setId":"07ab09eb-9430-4ea2-90c0-db2ca237cc96","title":"RESTLESS LEG SYMPTOM RELIEF (ARSENICUM ALBUM, BUFO RANA, CAUSTICUM, CHAMOMILLA, CROTALUS HORRIDUS, DIGITALIS PURPUREA, LACHESIS MUTUS, LILIUM TIGRINUM, PULSATILLA, RHUS TOX, SULPHUR, TARENTULA HISPANA, VISCUM ALBUM AND ZINCUM METALLICUM.) LIQUID [KING BIO INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Viscum album (European mistletoe) contains bioactive proteins, particularly lectins and viscotoxins, that enhance innate and adaptive immune responses against malignant cells. The extract promotes production of cytokines such as TNF-α and IL-6, and increases the cytotoxic activity of immune effector cells. This immunostimulatory mechanism is thought to work synergistically with conventional cancer therapies.","oneSentence":"Viscum album extract stimulates the immune system to recognize and attack cancer cells through activation of natural killer cells and cytotoxic T lymphocytes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:02.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive therapy in various cancers (breast, colorectal, gastric, ovarian)"},{"name":"Palliative care and quality of life improvement in advanced cancer"}]},"trialDetails":[{"nctId":"NCT02106572","phase":"PHASE3","title":"Therapeutic Instillation of Mistletoe","status":"ACTIVE_NOT_RECRUITING","sponsor":"Abnoba Gmbh","startDate":"2015-04","conditions":"Superficial Bladder Cancer","enrollment":548},{"nctId":"NCT06920810","phase":"PHASE4","title":"Viscum Album for TNBC on Adjuvant Pembrolizumab","status":"RECRUITING","sponsor":"Ilsan Cha hospital","startDate":"2025-03-19","conditions":"Breast Cancer, Triple Negative Breast Cancer","enrollment":40},{"nctId":"NCT06408688","phase":"PHASE4","title":"Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2024-06-24","conditions":"Advanced Solid Tumor","enrollment":100},{"nctId":"NCT02948309","phase":"PHASE3","title":"Mistletoe Therapy in Primary and Recurrent Inoperable Pancreatic Cancer","status":"COMPLETED","sponsor":"Karolinska University Hospital","startDate":"2016-06","conditions":"Pancreatic Cancer","enrollment":290},{"nctId":"NCT04376931","phase":"PHASE1, PHASE2","title":"A Prospective Dose Finding Study of Iscador Infusion","status":"UNKNOWN","sponsor":"HaEmek Medical Center, Israel","startDate":"2020-12-01","conditions":"Advanced Cancer","enrollment":24},{"nctId":"NCT04054284","phase":"NA","title":"Safety and Efficacy of Herbal Tea in Type 2 Diabetics","status":"COMPLETED","sponsor":"Josip Juraj Strossmayer University of Osijek","startDate":"2019-07-01","conditions":"Type 2 Diabetes, Herbal Medicine Adverse Reaction","enrollment":60},{"nctId":"NCT00176046","phase":"PHASE4","title":"Mistletoe Extract in Early or Advanced Breast Cancer, A Feasibility Study","status":"COMPLETED","sponsor":"Heidelberg University","startDate":"1999-05","conditions":"Metastatic Breast Cancer","enrollment":114},{"nctId":"NCT02007005","phase":"PHASE1, PHASE2","title":"Maximum Tolerable Concentration of abnobaVISCUM Fraxini Intravesically in Patients With Superficial Bladder Cancer","status":"COMPLETED","sponsor":"Abnoba Gmbh","startDate":"2004-01","conditions":"Superficial Bladder Cancer","enrollment":37},{"nctId":"NCT02191540","phase":"PHASE3","title":"Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients","status":"COMPLETED","sponsor":"Abnoba Korea","startDate":"2011-01","conditions":"Malignant Pleural Effusion","enrollment":68},{"nctId":"NCT01401075","phase":"PHASE4","title":"RCT With Adjuvant Mistletoe Treatment in Gastric Cancer Patients","status":"COMPLETED","sponsor":"Abnoba Gmbh","startDate":"2006-03","conditions":"Gastric Cancer","enrollment":32},{"nctId":"NCT01527760","phase":"NA","title":"Effectiveness of Viscum Album Mother Tincture as an Anti-hypertensive in Essential Hypertension","status":"COMPLETED","sponsor":"Fr Muller Homoeopathic Medical College","startDate":"2011-02","conditions":"Hypertension","enrollment":37}],"_emaApprovals":[],"_faersSignals":[{"count":25,"reaction":"FATIGUE"},{"count":14,"reaction":"DRUG INTERACTION"},{"count":10,"reaction":"DIARRHOEA"},{"count":10,"reaction":"GASTROINTESTINAL HAEMORRHAGE"},{"count":10,"reaction":"PYREXIA"},{"count":9,"reaction":"ABDOMINAL PAIN UPPER"},{"count":9,"reaction":"HEADACHE"},{"count":8,"reaction":"MALIGNANT NEOPLASM PROGRESSION"},{"count":8,"reaction":"NAUSEA"},{"count":8,"reaction":"OFF LABEL USE"}],"_approvalHistory":[],"publicationCount":834,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"viscum album","genericName":"viscum album","companyName":"Ilsan Cha hospital","companyId":"ilsan-cha-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Viscum album extract stimulates the immune system to recognize and attack cancer cells through activation of natural killer cells and cytotoxic T lymphocytes. Used for Adjunctive therapy in various cancers (breast, colorectal, gastric, ovarian), Palliative care and quality of life improvement in advanced cancer.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}