{"id":"vinflunine-and-best-supportive-care","safety":{"commonSideEffects":[{"rate":"20-40%","effect":"Myelosuppression"},{"rate":"10-30%","effect":"Nausea and vomiting"},{"rate":"10-20%","effect":"Diarrhea"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-15%","effect":"Anemia"}]},"_chembl":{"chemblId":"CHEMBL2110725","moleculeType":"Small molecule","molecularWeight":"816.94"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This results in the inhibition of cancer cell growth and proliferation. Vinflunine is a derivative of the anthracycline antibiotic doxorubicin and has been shown to have antitumor activity against various types of cancer.","oneSentence":"Vinflunine is a chemotherapeutic agent that works by intercalating DNA and inhibiting the enzyme topoisomerase II, thereby inducing apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:34.841Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced or metastatic transitional cell carcinoma of the urothelial tract"}]},"trialDetails":[{"nctId":"NCT00315237","phase":"PHASE3","title":"Phase III Trial of Vinflunine Plus Best Supportive Care vs. Best Supportive Care in Patients With Transitional Cell Carcinoma (TCC) of the Urothelial Tract","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2005-07","conditions":"Transitional Cell Carcinoma of the Urothelial Tract, Bladder Cancer, Bladder Neoplasms","enrollment":364}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"vinflunine and best supportive care","genericName":"vinflunine and best supportive care","companyName":"Pierre Fabre Medicament","companyId":"pierre-fabre-medicament","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vinflunine is a chemotherapeutic agent that works by intercalating DNA and inhibiting the enzyme topoisomerase II, thereby inducing apoptosis in cancer cells. Used for Advanced or metastatic transitional cell carcinoma of the urothelial tract.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}