{"id":"vinburnine","rwe":[{"pmid":"40995667","year":"2025","title":"Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway.","finding":"","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","studyType":"Clinical Study"},{"pmid":"40866941","year":"2025","title":"Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.","finding":"","journal":"Journal of experimental & clinical cancer research : CR","studyType":"Clinical Study"},{"pmid":"40612674","year":"2025","title":"Signature-based repurposed drugs resemble the inhibition of TGFβ-induced NDRG1 as potential therapeutics for triple-negative breast cancer.","finding":"","journal":"International journal of biological sciences","studyType":"Clinical Study"},{"pmid":"39566274","year":"2024","title":"Investigating the stability of a cerebral vasodilator drug using chromatographic methods: Evaluation of methods' practicality and environmental aspects.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"39113550","year":"2024","title":"Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"}],"tags":[{"label":"vinburnine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Muscarinic acetylcholine receptor M3","category":"target"},{"label":"CHRM3","category":"gene"},{"label":"CHRM1","category":"gene"},{"label":"CHRM4","category":"gene"},{"label":"C04AX17","category":"atc"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"vincamone","offLabel":[],"synonyms":["vinburnine","vincamone","(-)-Vincamone","(-)-cis-Eburnamonine","l-Eburnamonine"],"timeline":[],"approvals":[],"brandName":"Vincamone","ecosystem":[],"mechanism":{"target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","targets":[{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"}],"modality":"Small Molecule","drugClass":"vinburnine","explanation":"Imagine your body's nervous system as a complex network of messengers. Vincamone helps to block or modulate the activity of these messengers, specifically those that interact with the M3 receptor, which plays a role in various bodily functions such as heart rate and digestion.","oneSentence":"Vincamone works by binding to the muscarinic acetylcholine receptor M3, which is involved in various physiological processes.","technicalDetail":"Vincamone acts as a competitive antagonist at the M3 muscarinic acetylcholine receptor, which is a subtype of the muscarinic acetylcholine receptor family."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2824","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=VINBURNINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:14:04.811851","biosimilars":[],"competitors":[{"drugName":"phenoxybenzamine","drugSlug":"phenoxybenzamine","fdaApproval":"1953-01-26","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"vinburnine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenoxybenzamine","brandName":"phenoxybenzamine","genericName":"phenoxybenzamine","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005681","UNII":"G54D0HMY25","CHEBI":"CHEBI:4740","INN_ID":"4976","RXNORM":"57954","UMLSCUI":"C0148398","ChEMBL_ID":"CHEMBL1892145","KEGG_DRUG":"D08676","DRUGBANK_ID":"DB13793","PUBCHEM_CID":"71203","SNOMEDCT_US":"698873005","IUPHAR_LIGAND_ID":"345","MESH_SUPPLEMENTAL_RECORD_UI":"C016422"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C04AX17","allCodes":["C04AX17"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec","pmid":"40995667","title":"Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR-NFκB Pathway.","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"date":"2025 Aug 27","pmid":"40866941","title":"Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.","journal":"Journal of experimental & clinical cancer research : CR"},{"date":"2025","pmid":"40612674","title":"Signature-based repurposed drugs resemble the inhibition of TGFβ-induced NDRG1 as potential therapeutics for triple-negative breast cancer.","journal":"International journal of biological sciences"},{"date":"2024 Dec 1","pmid":"39566274","title":"Investigating the stability of a cerebral vasodilator drug using chromatographic methods: Evaluation of methods' practicality and environmental aspects.","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"date":"2024 Oct 30","pmid":"39113550","title":"Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents.","journal":"Organic & biomolecular chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vincamone is a small molecule with the synonyms including eburnamine, and it is also known as vinburnine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}