{"id":"vfend-i-v-oral","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"VFEND® I.V., Oral works by targeting the enzyme lanosterol 14α-demethylase, which is necessary for the conversion of lanosterol to ergosterol. This inhibition disrupts the integrity of the fungal cell membrane, ultimately leading to cell death. As a result, VFEND® I.V., Oral is effective against a wide range of fungal infections.","oneSentence":"VFEND® I.V., Oral is an antifungal medication that inhibits the synthesis of ergosterol, an essential component of fungal cell membranes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:33.212Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of invasive aspergillosis, invasive candidiasis, and esophageal candidiasis"}]},"trialDetails":[{"nctId":"NCT00163111","phase":"PHASE3","title":"A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood.","status":"COMPLETED","sponsor":"Pfizer","startDate":"1998-09","conditions":"Candidiasis","enrollment":412}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":77,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"VFEND® I.V., Oral","genericName":"VFEND® I.V., Oral","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"VFEND® I.V., Oral is an antifungal medication used to treat Candidiasis. It works by inducing an immune response, but its exact mechanism is not related to vaccine components as it is primarily used to treat fungal infections, not to prevent them.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}