{"id":"veregen-only","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Erosion"}]},"_chembl":{"chemblId":"CHEMBL464738","moleculeType":"Small molecule","molecularWeight":"396.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Veregen contains catechins and other polyphenols derived from green tea that target HPV-infected keratinocytes. The active compounds induce cell cycle arrest and programmed cell death in dysplastic cells while modulating immune responses against HPV. The exact molecular targets include potential effects on viral protein expression and cellular signaling pathways involved in HPV-driven proliferation.","oneSentence":"Veregen is a polyphenon E extract that induces apoptosis and inhibits growth of human papillomavirus (HPV)-infected cells through multiple molecular pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:15:09.325Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"External genital warts (condyloma acuminata) caused by human papillomavirus"}]},"trialDetails":[{"nctId":"NCT02147353","phase":"NA","title":"Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2011-09","conditions":"External Genital Warts","enrollment":42},{"nctId":"NCT02622568","phase":"PHASE4","title":"Investigating Veregen ™ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2015-07","conditions":"Verruca, Warts","enrollment":28},{"nctId":"NCT01490008","phase":"PHASE1","title":"Systemic Exposure of Catechins From Veregen 15% Ointment in Patients With External Anogenital Warts and From Oral Intake of Green Tea Beverage in Healthy Volunteers","status":"COMPLETED","sponsor":"MediGene","startDate":"2011-12","conditions":"Anogenital Warts","enrollment":30},{"nctId":"NCT01082302","phase":"PHASE4","title":"Pharmacokinetic Study of Topically Applied Veregen 15% Compared With Oral Intake of Green Tea Beverage","status":"COMPLETED","sponsor":"MediGene","startDate":"2010-01","conditions":"Genital Warts, Perianal Warts","enrollment":43}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Veregen only","genericName":"Veregen only","companyName":"University of Texas Southwestern Medical Center","companyId":"university-of-texas-southwestern-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Veregen is a polyphenon E extract that induces apoptosis and inhibits growth of human papillomavirus (HPV)-infected cells through multiple molecular pathways. Used for External genital warts (condyloma acuminata) caused by human papillomavirus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}