{"id":"verapamil-hexal-verapamil","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Constipation"},{"rate":"3-8","effect":"Dizziness"},{"rate":"2-5","effect":"Headache"},{"rate":"2-5","effect":"Fatigue"},{"rate":"1-3","effect":"Bradycardia"},{"rate":"1-3","effect":"Hypotension"},{"rate":"1-2","effect":"Edema"}]},"_chembl":{"chemblId":"CHEMBL1280","moleculeType":"Small molecule","molecularWeight":"491.07"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Verapamil is a non-dihydropyridine calcium channel blocker that inhibits the inward movement of calcium ions through L-type calcium channels in the sinoatrial and atrioventricular nodes, as well as in vascular smooth muscle. This action slows conduction through the AV node, reduces myocardial contractility, and causes vasodilation, resulting in decreased heart rate and blood pressure. These effects make it useful for treating hypertension, angina, and certain arrhythmias.","oneSentence":"Verapamil blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx and decreasing heart rate, contractility, and blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:15:12.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Supraventricular tachycardia"},{"name":"Atrial fibrillation rate control"}]},"trialDetails":[{"nctId":"NCT02527993","phase":"PHASE4","title":"Treatment of Hypoglycemia Following Gastric Bypass Surgery","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2015-10","conditions":"Hypoglycemia, Obesity, Surgery","enrollment":11}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Verapamil HEXAL"],"phase":"marketed","status":"active","brandName":"Verapamil HEXAL (verapamil)","genericName":"Verapamil HEXAL (verapamil)","companyName":"Zealand University Hospital","companyId":"zealand-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Verapamil blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx and decreasing heart rate, contractility, and blood pressure. Used for Hypertension, Angina pectoris, Supraventricular tachycardia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}