{"id":"venlafaxine-and-lamotrigine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Insomnia or somnolence"},{"rate":null,"effect":"Rash (lamotrigine-related)"},{"rate":null,"effect":"Sexual dysfunction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that increases synaptic concentrations of both neurotransmitters to alleviate depression and anxiety. Lamotrigine is an anticonvulsant that reduces excitatory glutamate transmission and stabilizes neuronal firing, providing additional mood-stabilizing and neuroprotective benefits. This combination is used off-label or in clinical practice to enhance efficacy in treatment-resistant depression and bipolar disorder.","oneSentence":"Venlafaxine inhibits reuptake of serotonin and norepinephrine while lamotrigine stabilizes neuronal membranes by blocking sodium channels and modulating glutamate release, together providing antidepressant and mood-stabilizing effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:30.720Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder (treatment-resistant or augmentation)"},{"name":"Bipolar depression"},{"name":"Anxiety disorders"}]},"trialDetails":[{"nctId":"NCT05603104","phase":"PHASE3","title":"Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure","status":"RECRUITING","sponsor":"Dr. Inge Winter","startDate":"2025-04-27","conditions":"Schizophrenia and Related Disorders, Major Depressive Disorder, Bipolar Depression","enrollment":1254},{"nctId":"NCT02893371","phase":"","title":"Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies","status":"TERMINATED","sponsor":"University of New Mexico","startDate":"2016-09","conditions":"Bipolar Disorder","enrollment":1037352},{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":"Dementia, Depression, Schizophrenia","enrollment":407},{"nctId":"NCT00188643","phase":"PHASE4","title":"Venlafaxine Versus Lamotrigine in the Treatment of Bipolar I/II Depression","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2002-01","conditions":"Bipolar Disorder","enrollment":40},{"nctId":"NCT00001478","phase":"","title":"Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders","status":"COMPLETED","sponsor":"National Institute of Mental Health (NIMH)","startDate":"1994-10","conditions":"Healthy, Mood Disorders","enrollment":170}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":93,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Venlafaxine and Lamotrigine","genericName":"Venlafaxine and Lamotrigine","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Venlafaxine inhibits reuptake of serotonin and norepinephrine while lamotrigine stabilizes neuronal membranes by blocking sodium channels and modulating glutamate release, together providing antidepressant and mood-stabilizing effects. Used for Major depressive disorder (treatment-resistant or augmentation), Bipolar depression, Anxiety disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}