{"id":"ven-307","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Blurred vision"}]},"_chembl":{"chemblId":"CHEMBL3652454","moleculeType":"Small molecule","molecularWeight":"403.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"VEN 307 is a selective Rho kinase inhibitor formulated as an eye drop for glaucoma treatment. By inhibiting Rho kinase, the drug promotes relaxation of the trabecular meshwork and Schlemm's canal, thereby increasing conventional aqueous humor outflow and reducing intraocular pressure. This mechanism addresses a key pathophysiological feature of glaucoma-related vision loss.","oneSentence":"VEN 307 is a topical ophthalmic agent designed to reduce intraocular pressure in glaucoma by enhancing aqueous humor outflow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:23.945Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT01690221","phase":"PHASE3","title":"Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures","status":"COMPLETED","sponsor":"Ventrus Biosciences, Inc","startDate":"2012-10","conditions":"Chronic Anal Fissures","enrollment":434}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["diltiazem hydrochloride 2% cream"],"phase":"phase_3","status":"active","brandName":"VEN 307","genericName":"VEN 307","companyName":"Ventrus Biosciences, Inc","companyId":"ventrus-biosciences-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"VEN 307 is a topical ophthalmic agent designed to reduce intraocular pressure in glaucoma by enhancing aqueous humor outflow. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}