{"id":"velnacrine","rwe":[{"pmid":"41356466","year":"2025","title":"Comprehensive fecal metagenomic and metabolomic analysis reveals the role of gut microbiota and metabolites in detecting brain metastasis of small cell lung cancer.","finding":"","journal":"Frontiers in microbiology","studyType":"Clinical Study"},{"pmid":"40722175","year":"2025","title":"Angiogenesis-related genes and immune microenvironment in moyamoya disease: a transcriptomic and functional analysis.","finding":"","journal":"Orphanet journal of rare diseases","studyType":"Clinical Study"},{"pmid":"32037088","year":"2020","title":"Natural and synthetic drugs used for the treatment of the dementia.","finding":"","journal":"Biochemical and biophysical research communications","studyType":"Clinical Study"},{"pmid":"29248451","year":"2018","title":"Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease.","finding":"","journal":"Journal of ethnopharmacology","studyType":"Clinical Study"},{"pmid":"23187452","year":"2013","title":"Effects of acetylcholine on an animal mode of inflammation.","finding":"","journal":"Clinical hemorheology and microcirculation","studyType":"Clinical Study"}],"tags":[{"label":"velnacrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholinesterase","category":"target"},{"label":"ACHE","category":"gene"},{"label":"Active","category":"status"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinesterase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["velnacrine","velnacrine maleate"],"offLabel":[],"synonyms":["velnacrine","velnacrine maleate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Acetylcholinesterase, Acetylcholinesterase, Butyrylcholinesterase","targets":[{"gene":"ACHE","source":"DrugCentral","target":"Acetylcholinesterase","protein":"Acetylcholinesterase"}],"modality":"Small Molecule","drugClass":"velnacrine","explanation":"Think of acetylcholine like a messenger in your brain that helps with memory and learning. When Velnacrine blocks the enzyme that breaks it down, more of these messengers are available to help with these functions. This can potentially help people with conditions like Alzheimer's disease, but more research is needed to confirm its effectiveness and safety.","oneSentence":"VELNACRINE works by blocking the enzyme that breaks down a neurotransmitter called acetylcholine.","technicalDetail":"VELNACRINE acts as a reversible inhibitor of Acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine, thereby increasing the concentration and duration of action of acetylcholine in the synaptic cleft."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3848","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=VELNACRINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:13:10.986200","biosimilars":[],"competitors":[{"drugName":"alfuzosin","drugSlug":"alfuzosin","fdaApproval":"2003-06-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ambenonium","drugSlug":"ambenonium","fdaApproval":"1956-05-01","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"benzethonium","drugSlug":"benzethonium","fdaApproval":"","relationship":"same-target"},{"drugName":"butenafine","drugSlug":"butenafine","fdaApproval":"1996-10-18","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"caffeine","drugSlug":"caffeine","fdaApproval":"1948-11-26","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"citalopram","drugSlug":"citalopram","fdaApproval":"1998-07-17","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"decamethonium","drugSlug":"decamethonium","fdaApproval":"1975-05-21","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"demecarium","drugSlug":"demecarium","fdaApproval":"1959-08-05","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"dichlorvos","drugSlug":"dichlorvos","fdaApproval":"","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"velnacrine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alfuzosin","brandName":"alfuzosin","genericName":"alfuzosin","approvalYear":"2003","relationship":"same-target"},{"drugId":"ambenonium","brandName":"ambenonium","genericName":"ambenonium","approvalYear":"1956","relationship":"same-target"},{"drugId":"benzethonium","brandName":"benzethonium","genericName":"benzethonium","approvalYear":"","relationship":"same-target"},{"drugId":"butenafine","brandName":"butenafine","genericName":"butenafine","approvalYear":"1996","relationship":"same-target"},{"drugId":"caffeine","brandName":"caffeine","genericName":"caffeine","approvalYear":"1948","relationship":"same-target"},{"drugId":"citalopram","brandName":"citalopram","genericName":"citalopram","approvalYear":"1998","relationship":"same-target"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-target"},{"drugId":"decamethonium","brandName":"decamethonium","genericName":"decamethonium","approvalYear":"1975","relationship":"same-target"},{"drugId":"demecarium","brandName":"demecarium","genericName":"demecarium","approvalYear":"1959","relationship":"same-target"},{"drugId":"dichlorvos","brandName":"dichlorvos","genericName":"dichlorvos","approvalYear":"","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"Y2P6NV151K","CHEBI":"CHEBI:91990","INN_ID":"6403","UMLSCUI":"C0078151","ChEMBL_ID":"CHEMBL51934","KEGG_DRUG":"D06288","PUBCHEM_CID":"3655","SECONDARY_CAS_RN":"118909-22-1","MESH_SUPPLEMENTAL_RECORD_UI":"C056424"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":54,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"41356466","title":"Comprehensive fecal metagenomic and metabolomic analysis reveals the role of gut microbiota and metabolites in detecting brain metastasis of small cell lung cancer.","journal":"Frontiers in microbiology"},{"date":"2025 Jul 28","pmid":"40722175","title":"Angiogenesis-related genes and immune microenvironment in moyamoya disease: a transcriptomic and functional analysis.","journal":"Orphanet journal of rare diseases"},{"date":"2020 Apr 9","pmid":"32037088","title":"Natural and synthetic drugs used for the treatment of the dementia.","journal":"Biochemical and biophysical research communications"},{"date":"2018 Apr 6","pmid":"29248451","title":"Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease.","journal":"Journal of ethnopharmacology"},{"date":"2013","pmid":"23187452","title":"Effects of acetylcholine on an animal mode of inflammation.","journal":"Clinical hemorheology and microcirculation"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"VELNACRINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"VELNACRINE is a small molecule drug that targets Acetylcholinesterase, a key enzyme involved in the breakdown of acetylcholine, a neurotransmitter. It is classified as a velnacrine drug, but its commercial status is unknown. Velnacrine's mechanism of action is to inhibit the activity of Acetylcholinesterase, thereby increasing the levels of acetylcholine in the brain. However, it is not FDA-approved for any indications, and its safety profile and pharmacokinetic properties are not well established. Further research is needed to determine its potential therapeutic applications and risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}