{"id":"vehicle-vaginal-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by providing a physical barrier to reduce friction and discomfort during sexual intercourse. The exact mechanism of action is not well understood, but it is thought to help restore the natural moisture balance of the vagina.","oneSentence":"Vehicle Vaginal Cream is a topical lubricant used to treat vaginal dryness and discomfort.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:29.406Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of vaginal dryness and discomfort"}]},"trialDetails":[{"nctId":"NCT03332303","phase":"PHASE3","title":"Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy","status":"COMPLETED","sponsor":"Prasco LLC","startDate":"2017-10-26","conditions":"Vulvar and Vaginal Atrophy","enrollment":540},{"nctId":"NCT01039584","phase":"NA","title":"A Randomized Study Evaluating the Therapeutic Equivalence of Two Butoconazole Nitrate Vaginal Cream, 2% Formulations","status":"COMPLETED","sponsor":"Padagis LLC","startDate":"2008-02","conditions":"Vulvovaginal Candidiasis","enrollment":611},{"nctId":"NCT01816139","phase":"PHASE3","title":"Multicenter Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women","status":"COMPLETED","sponsor":"Warner Chilcott","startDate":"2013-01-31","conditions":"Vulvovaginal Atrophy","enrollment":576},{"nctId":"NCT01400776","phase":"PHASE3","title":"Safety & Efficacy WC3011 (Estradiol Vaginal Cream) in the Treatment of Vulvovaginal Atrophy in Postmenopausal Women","status":"COMPLETED","sponsor":"Warner Chilcott","startDate":"2011-06-29","conditions":"Postmenopausal Vulvovaginal Atrophy","enrollment":722},{"nctId":"NCT01845649","phase":"PHASE3","title":"Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareunia","status":"COMPLETED","sponsor":"Warner Chilcott","startDate":"2013-04-12","conditions":"Vulvovaginal Atrophy","enrollment":550},{"nctId":"NCT02710981","phase":"NA","title":"Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium","status":"COMPLETED","sponsor":"Assiut University","startDate":"2015-06","conditions":"Anovulation","enrollment":42},{"nctId":"NCT02210689","phase":"PHASE3","title":"A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2014-01","conditions":"BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include, Vaginal Discharge Color, Odor, and Consistency","enrollment":604},{"nctId":"NCT03294538","phase":"PHASE3","title":"Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2016-05-18","conditions":"Atrophic Vaginitis","enrollment":663}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Vehicle Vaginal Cream","genericName":"Vehicle Vaginal Cream","companyName":"Actavis Inc.","companyId":"actavis-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vehicle Vaginal Cream is a topical lubricant used to treat vaginal dryness and discomfort. Used for Treatment of vaginal dryness and discomfort.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}