{"id":"vehicle-of-bilastine-ophthalmic-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bilastine competitively antagonizes H1 histamine receptors on mast cells and other immune cells in the eye, preventing histamine release and reducing allergic inflammation. When formulated as an ophthalmic solution, it provides local anti-allergic effects in the conjunctiva and anterior segment of the eye. This mechanism reduces itching, redness, and other symptoms of ocular allergic conditions.","oneSentence":"Bilastine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in ocular tissues.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:31.566Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic conjunctivitis"},{"name":"Ocular allergic inflammation"}]},"trialDetails":[{"nctId":"NCT03479307","phase":"PHASE3","title":"A Study Evaluating Bilastine Ophthalmic Solution 0.6% in the Conjunctival Allergen Challenge (Ora-CAC®) Model.","status":"COMPLETED","sponsor":"Faes Farma, S.A.","startDate":"2018-04-07","conditions":"Allergic Conjunctivitis","enrollment":228},{"nctId":"NCT03231969","phase":"PHASE2","title":"A Single-Center, Phase 2 Study Evaluating Bilastine Ophthalmic Solution in the CAC® Model","status":"COMPLETED","sponsor":"Faes Farma, S.A.","startDate":"2017-07-20","conditions":"Allergic Conjunctivitis","enrollment":121}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Vehicle of Bilastine Ophthalmic Solution","genericName":"Vehicle of Bilastine Ophthalmic Solution","companyName":"Faes Farma, S.A.","companyId":"faes-farma-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bilastine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in ocular tissues. Used for Allergic conjunctivitis, Ocular allergic inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}