{"id":"vasopressin-epinephrine-methylprednisolone-hydrocortisone","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Immunosuppression"},{"rate":null,"effect":"Arrhythmias"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Vasopressin and epinephrine act as potent vasoconstrictors to maintain blood pressure and organ perfusion during circulatory collapse. The corticosteroids (methylprednisolone and hydrocortisone) provide anti-inflammatory effects and may improve outcomes in shock states by stabilizing cellular membranes and reducing inflammatory mediator release. This combination addresses both the immediate hemodynamic crisis and the underlying inflammatory cascade.","oneSentence":"This is a combination therapy that uses vasopressin and epinephrine as vasoconstrictors, methylprednisolone and hydrocortisone as corticosteroids to improve hemodynamics and reduce inflammation during cardiac arrest or septic shock.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:19.241Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiac arrest with refractory shock"},{"name":"Septic shock"}]},"trialDetails":[{"nctId":"NCT02785224","phase":"","title":"Arterial Pressure and Stress-Dose Steroids in Cardiac Arrest.","status":"WITHDRAWN","sponsor":"University of Athens","startDate":"2025-12","conditions":"Cardiac Arrest","enrollment":""},{"nctId":"NCT05139849","phase":"PHASE3","title":"VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial","status":"RECRUITING","sponsor":"Tiohundra AB","startDate":"2021-11-17","conditions":"Cardiac Arrest;In-hospital Cardiac Arrest; Methylprednisolone; Vasopressin; Adrenaline; Randomized Clinical Trial","enrollment":1276},{"nctId":"NCT00729794","phase":"PHASE3","title":"Vasopressin, Epinephrine, and Steroids for Cardiac Arrest","status":"COMPLETED","sponsor":"University of Athens","startDate":"2008-09","conditions":"Cardiac Arrest","enrollment":300},{"nctId":"NCT00411879","phase":"PHASE2","title":"Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest","status":"COMPLETED","sponsor":"University of Athens","startDate":"2006-06","conditions":"Heart Arrest","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone","genericName":"Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone","companyName":"University of Athens","companyId":"university-of-athens","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination therapy that uses vasopressin and epinephrine as vasoconstrictors, methylprednisolone and hydrocortisone as corticosteroids to improve hemodynamics and reduce inflammation during cardiac arrest or septic shock. Used for Cardiac arrest with refractory shock, Septic shock.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}