{"id":"varivax-provarivax","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10-15","effect":"Fever"},{"rate":"3-5","effect":"Rash (varicella-like)"},{"rate":"5-10","effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The vaccine contains a weakened strain of varicella-zoster virus (Oka strain) that replicates in host cells but does not cause disease in immunocompetent individuals. This triggers both humoral and cell-mediated immune responses, generating antibodies and T-cell memory that protect against subsequent natural varicella infection. ProVarivax is a refrigerator-stable formulation variant of the same vaccine technology.","oneSentence":"Varivax is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:13.918Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in children and adults"},{"name":"Prevention of herpes zoster (shingles) in older adults"}]},"trialDetails":[{"nctId":"NCT01439360","phase":"PHASE3","title":"An Efficacy Study of GlaxoSmithKline (GSK) Biologicals' Candidate Influenza Vaccine GSK2321138A in Children","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-10-01","conditions":"Influenza","enrollment":12046}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Varivax/ProVarivax","genericName":"Varivax/ProVarivax","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"Varivax is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection. Used for Prevention of varicella (chickenpox) in children and adults, Prevention of herpes zoster (shingles) in older adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}