{"id":"varivax-new-seed-process","safety":{"commonSideEffects":[{"rate":"19-35","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10-15","effect":"Fever"},{"rate":"3-5","effect":"Rash (varicella-like)"},{"rate":"1-2","effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2108130","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains a weakened form of the varicella-zoster virus (Oka strain) that replicates in host cells but does not cause disease in immunocompetent individuals. This triggers both cellular and humoral immune responses, generating antibodies and T-cell mediated immunity against the virus. The new seed process refers to an updated manufacturing method for producing the vaccine strain.","oneSentence":"VARIVAX is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:12.727Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in children and adults"}]},"trialDetails":[{"nctId":"NCT02062502","phase":"PHASE3","title":"Evaluation of Immunogenicity and Safety of VARIVAX™ New Seed Process (NSP) in Children (V210-063)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2014-03-07","conditions":"Varicella","enrollment":611}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"VARIVAX™ New Seed Process","genericName":"VARIVAX™ New Seed Process","companyName":"Merck Sharp & Dohme LLC","companyId":"merck-sharp-dohme-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"VARIVAX is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection. Used for Prevention of varicella (chickenpox) in children and adults.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}