{"id":"varilrix-hsa-free","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10-15","effect":"Fever"},{"rate":"5-10","effect":"Rash"},{"rate":"5","effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The vaccine contains a weakened form of the varicella-zoster virus that replicates in the body without causing disease, thereby priming both cellular and humoral immunity against the virus. The HSA-free formulation removes human serum albumin from the vaccine composition. This allows the immune system to recognize and respond to varicella-zoster virus antigens, providing protection against natural infection.","oneSentence":"Varilrix HSA-free is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent varicella (chickenpox) infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:23.259Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in children and adults"}]},"trialDetails":[{"nctId":"NCT02570126","phase":"PHASE3","title":"A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-11-13","conditions":"Chicken-pox Illness (Varicella Virus Disease), Chickenpox","enrollment":1236},{"nctId":"NCT00568334","phase":"PHASE2","title":"Study of Two Formulations of GSK Biologicals' Varicella Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-11-01","conditions":"Varicella","enrollment":244}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Varilrix HSA-free","genericName":"Varilrix HSA-free","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"Varilrix HSA-free is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent varicella (chickenpox) infection. Used for Prevention of varicella (chickenpox) in children and adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}