{"id":"varied-albuterol-dose-response","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Tremor"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Nervousness/anxiety"},{"rate":"1-5","effect":"Palpitations"},{"rate":"1-5","effect":"Tachycardia"},{"rate":"1-5","effect":"Muscle cramps"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Albuterol binds to and activates beta-2 adrenergic receptors on the smooth muscle of airways, triggering a cascade that increases intracellular cAMP and leads to smooth muscle relaxation and airway opening. This study appears to examine variable dose-response relationships in albuterol administration, likely investigating optimal dosing strategies or individual variability in patient response.","oneSentence":"Albuterol is a beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to cause bronchodilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:57.892Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (acute bronchospasm relief and maintenance)"},{"name":"Chronic obstructive pulmonary disease (COPD) (acute bronchospasm relief)"}]},"trialDetails":[{"nctId":"NCT02447250","phase":"PHASE4","title":"Preterm Infant Inhaled Albuterol Dosing","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2013-10-24","conditions":"Bronchopulmonary Dysplasia, Very Low Birth Weight","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Albuterol sulfate","Salbutamol","Proventil","ProAir","Ventolin"],"phase":"marketed","status":"active","brandName":"Varied albuterol dose response","genericName":"Varied albuterol dose response","companyName":"Oregon Health and Science University","companyId":"oregon-health-and-science-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Albuterol is a beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to cause bronchodilation. Used for Asthma (acute bronchospasm relief and maintenance), Chronic obstructive pulmonary disease (COPD) (acute bronchospasm relief).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}