{"id":"varicella-vaccine","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10-15","effect":"Fever"},{"rate":"3-5","effect":"Rash (varicella-like)"},{"rate":"1-2","effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2108573","moleculeType":"Vaccine component"},"_dailymed":{"setId":"73eae9fc-507b-4c9c-883d-63eb2e3cc6f6","title":"PROQUAD (MEASLES, MUMPS, RUBELLA AND VARICELLA VIRUS VACCINE LIVE) INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION [MERCK SHARP & DOHME LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains live attenuated (weakened) varicella-zoster virus that replicates in the body at low levels, triggering both humoral (antibody) and cell-mediated immune responses without causing disease. This primes the immune system to recognize and rapidly eliminate wild-type varicella-zoster virus upon natural exposure, preventing infection or significantly reducing disease severity.","oneSentence":"Varicella vaccine stimulates the immune system to produce antibodies and cellular immunity against the varicella-zoster virus, preventing chickenpox infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:47.692Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in children and adults"},{"name":"Prevention of herpes zoster (shingles) in older adults"}]},"trialDetails":[{"nctId":"NCT05703607","phase":"PHASE1, PHASE2","title":"A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults","status":"TERMINATED","sponsor":"Pfizer","startDate":"2023-01-25","conditions":"Shingles, Herpes Zoster Infection, Human","enrollment":485},{"nctId":"NCT07485283","phase":"PHASE4","title":"Recombinant 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