{"id":"varenicline-tartarate","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Insomnia"},{"rate":"5-10%","effect":"Dyspepsia"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved by activating the alpha4beta2 subtype of nicotinic acetylcholine receptors, which are involved in the brain's reward and stress response pathways. By blocking the action of nicotine at these receptors, varenicline reduces the urge to smoke and alleviates withdrawal symptoms.","oneSentence":"Varenicline works by binding to nicotinic acetylcholine receptors in the brain, reducing the rewarding effects of smoking and alleviating withdrawal symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:22.449Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment to help adults quit smoking"}]},"trialDetails":[{"nctId":"NCT00285012","phase":"PHASE3","title":"Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).","status":"COMPLETED","sponsor":"Pfizer","startDate":"2006-05","conditions":"Smoking Cessation","enrollment":504}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chantix, Champix"],"phase":"phase_3","status":"active","brandName":"Varenicline Tartarate","genericName":"Varenicline Tartarate","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Varenicline works by binding to nicotinic acetylcholine receptors in the brain, reducing the rewarding effects of smoking and alleviating withdrawal symptoms. Used for Treatment to help adults quit smoking.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}