{"id":"vanish-xt-dental-varnish","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild tooth staining or discoloration"},{"rate":null,"effect":"Temporary unpleasant taste"},{"rate":null,"effect":"Mild gum irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The varnish formulation allows prolonged contact between fluoride and tooth enamel, promoting remineralization of early carious lesions and strengthening enamel against acid attack. The sticky resin base keeps the fluoride in contact with teeth longer than rinses or gels, enhancing bioavailability and protective effects.","oneSentence":"Vanish XT is a fluoride varnish that adheres to tooth surfaces to provide sustained fluoride release for caries prevention and remineralization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:47.707Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental caries prevention"},{"name":"Enamel remineralization"},{"name":"Dentin hypersensitivity management"}]},"trialDetails":[{"nctId":"NCT03711097","phase":"PHASE4","title":"Effectiveness of Resin-Modified Glass Ionomer Varnish in Preventing White Spot Lesions in Fixed Appliance Orthodontia","status":"WITHDRAWN","sponsor":"University of Nebraska","startDate":"2019-04-22","conditions":"White Spot Lesion","enrollment":""},{"nctId":"NCT04579536","phase":"NA","title":"Effectiveness of Using (Vanish XT) in Prevention of Occlusal Caries: a RCT","status":"UNKNOWN","sponsor":"King Abdulaziz University","startDate":"2019-02-01","conditions":"Caries Prevention","enrollment":84},{"nctId":"NCT03685058","phase":"NA","title":"Effect of Light Curable Resin Modified Glass Ionomer Varnish on Non-Cavitated Proximal Carious Lesions' Progression","status":"UNKNOWN","sponsor":"King Abdulaziz University","startDate":"2018-01-11","conditions":"Dental Caries, Dental White Spot","enrollment":88}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["resin-modified glass ionomer"],"phase":"marketed","status":"active","brandName":"Vanish XT Dental Varnish","genericName":"Vanish XT Dental Varnish","companyName":"University of Nebraska","companyId":"university-of-nebraska","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vanish XT is a fluoride varnish that adheres to tooth surfaces to provide sustained fluoride release for caries prevention and remineralization. Used for Dental caries prevention, Enamel remineralization, Dentin hypersensitivity management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}