{"id":"vancomycin-antimicrobial-lock-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Local catheter site reactions"},{"rate":null,"effect":"Thrombophlebitis"},{"rate":null,"effect":"Catheter dysfunction"}]},"_chembl":{"chemblId":"CHEMBL262777","moleculeType":"Small molecule","molecularWeight":"1449.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vancomycin is a glycopeptide antibiotic that prevents bacterial cell wall cross-linking by inhibiting transglycosidase and transpeptidase enzymes. When used as an antimicrobial-lock solution, it is instilled into the catheter lumen where it maintains high local concentrations to prevent biofilm formation and treat catheter-related bloodstream infections caused by susceptible organisms, particularly gram-positive bacteria.","oneSentence":"Vancomycin antimicrobial-lock solution works by binding to bacterial cell wall precursors and inhibiting peptidoglycan synthesis, killing susceptible bacteria when used as a lock solution in central venous catheters.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:08.759Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of central venous catheter-related bloodstream infections"},{"name":"Catheter lock therapy for hemodialysis and parenteral nutrition catheters"}]},"trialDetails":[{"nctId":"NCT05971537","phase":"PHASE4","title":"Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis","status":"RECRUITING","sponsor":"Alice Ho Miu Ling Nethersole Hospital","startDate":"2023-06-15","conditions":"Peritoneal Dialysis-associated Peritonitis","enrollment":46},{"nctId":"NCT02901717","phase":"PHASE3","title":"Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI","status":"UNKNOWN","sponsor":"Leonard-Meron Biosciences, Inc.","startDate":"2018-02-13","conditions":"Catheter-related Infections","enrollment":144},{"nctId":"NCT01592032","phase":"PHASE4","title":"Concentration of Antimicrobials in Catheter-lock Solutions","status":"UNKNOWN","sponsor":"Clinica Universidad de Navarra, Universidad de Navarra","startDate":"2012-05","conditions":"Catheter-Related Infections, Bacteremia.","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["vancomycin: vancomicina sala 500 mg vial.","sodium heparin 1%, 5000 IU/5ml.","sodium chloride 0,9% 10 ml vial."],"phase":"marketed","status":"active","brandName":"Vancomycin antimicrobial-lock solution","genericName":"Vancomycin antimicrobial-lock solution","companyName":"Clinica Universidad de Navarra, Universidad de Navarra","companyId":"clinica-universidad-de-navarra-universidad-de-navarra","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vancomycin antimicrobial-lock solution works by binding to bacterial cell wall precursors and inhibiting peptidoglycan synthesis, killing susceptible bacteria when used as a lock solution in central venous catheters. Used for Prevention and treatment of central venous catheter-related bloodstream infections, Catheter lock therapy for hemodialysis and parenteral nutrition catheters.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}