{"id":"valsartan-amlodpine","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Peripheral edema"},{"rate":"3-5","effect":"Dizziness"},{"rate":"2-4","effect":"Fatigue"},{"rate":"2-3","effect":"Headache"},{"rate":"1-3","effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Valsartan blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone release, thereby lowering blood pressure. Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation. Together, these complementary mechanisms provide additive antihypertensive effects.","oneSentence":"Valsartan/amlodipine is a combination of an angiotensin II receptor blocker and a calcium channel blocker that reduces blood pressure through dual vasodilation and reduced vasoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:21.702Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT00716950","phase":"PHASE4","title":"Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients","status":"UNKNOWN","sponsor":"University of Pavia","startDate":"2008-07","conditions":"Essential Hypertension","enrollment":187}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"valsartan/amlodpine","genericName":"valsartan/amlodpine","companyName":"University of Pavia","companyId":"university-of-pavia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Valsartan/amlodipine is a combination of an angiotensin II receptor blocker and a calcium channel blocker that reduces blood pressure through dual vasodilation and reduced vasoconstriction. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}