{"id":"valproic-acid-sodium-salt","safety":{"commonSideEffects":[{"rate":"25-50%","effect":"Tremor"},{"rate":"20-40%","effect":"Weight gain"},{"rate":"5-15%","effect":"Alopecia (hair loss)"},{"rate":"10-20%","effect":"Nausea and vomiting"},{"rate":"1-3%","effect":"Hepatotoxicity"},{"rate":"5-10%","effect":"Thrombocytopenia"},{"rate":"<1%","effect":"Pancreatitis"},{"rate":"10-20%","effect":"Sedation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Valproic acid (sodium salt) works through multiple mechanisms: it inhibits histone deacetylase enzymes, which increases histone acetylation and alters gene expression; it also increases brain levels of GABA, an inhibitory neurotransmitter, by enhancing its synthesis and reducing its catabolism. These combined effects produce anticonvulsant, mood-stabilizing, and neuroprotective properties.","oneSentence":"Valproic acid inhibits histone deacetylases and enhances GABA neurotransmission, leading to increased inhibitory signaling in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:15.293Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epilepsy and seizure disorders"},{"name":"Bipolar disorder (acute mania)"},{"name":"Migraine prophylaxis"},{"name":"Investigational use in certain cancers (histone deacetylase inhibition)"}]},"trialDetails":[{"nctId":"NCT07166393","phase":"PHASE2, PHASE3","title":"Valproic AcId for Traumatic BRAin INjury Trial","status":"NOT_YET_RECRUITING","sponsor":"Northwestern University","startDate":"2026-05","conditions":"Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury","enrollment":432},{"nctId":"NCT04531592","phase":"PHASE2","title":"Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients","status":"WITHDRAWN","sponsor":"Westat","startDate":"2022-01","conditions":"Acute Kidney Injury, Ischemia Reperfusion Injury","enrollment":""},{"nctId":"NCT04531579","phase":"PHASE2","title":"Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients","status":"WITHDRAWN","sponsor":"Westat","startDate":"2022-01","conditions":"Acute Kidney Injury, Ischemia Reperfusion Injury","enrollment":""},{"nctId":"NCT01791868","phase":"NA","title":"Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-02","conditions":"Generalized Convulsive Status Epilepticus, Intensive Care Unit","enrollment":245},{"nctId":"NCT00228046","phase":"PHASE4","title":"Medication Strategies for Treating Aggressive Behavior in Youth With Attention Deficit Hyperactivity Disorder","status":"COMPLETED","sponsor":"Stony Brook University","startDate":"2004-01","conditions":"Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Oppositional Defiant Disorder","enrollment":40},{"nctId":"NCT00431522","phase":"PHASE4","title":"Valproic Acid Sodium Salt in Bipolar Disorder","status":"COMPLETED","sponsor":"Sanofi","startDate":"2004-12","conditions":"Bipolar Disorder","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Valproic acid, sodium salt","genericName":"Valproic acid, sodium salt","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Valproic acid inhibits histone deacetylases and enhances GABA neurotransmission, leading to increased inhibitory signaling in the central nervous system. Used for Epilepsy and seizure disorders, Bipolar disorder (acute mania), Migraine prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}