{"id":"valproate-microgranules","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Tremor"},{"rate":"20-40","effect":"Weight gain"},{"rate":"5-15","effect":"Alopecia (hair loss)"},{"rate":"5-10","effect":"Thrombocytopenia"},{"rate":"1-3","effect":"Hepatotoxicity"},{"rate":"<1","effect":"Pancreatitis"},{"rate":"10-20","effect":"Nausea/vomiting"},{"rate":"10-20","effect":"Sedation"}]},"_chembl":{"chemblId":"CHEMBL433","moleculeType":"Small molecule","molecularWeight":"166.20"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Valproate works through multiple mechanisms: it inhibits histone deacetylase enzymes, which affects gene expression; increases GABA synthesis and decreases GABA catabolism, enhancing inhibitory neurotransmission; and stabilizes neuronal membranes. The microgranule formulation provides modified-release delivery for improved tolerability and dosing convenience.","oneSentence":"Valproate inhibits histone deacetylase and enhances GABAergic neurotransmission, leading to increased GABA levels and neuronal stabilization.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:20.308Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epilepsy (seizure disorders)"},{"name":"Bipolar disorder (acute mania)"},{"name":"Migraine prophylaxis"}]},"trialDetails":[{"nctId":"NCT00385411","phase":"PHASE4","title":"Study of Valproate in Young Patients Suffering From Epilepsy","status":"COMPLETED","sponsor":"Sanofi","startDate":"2006-03","conditions":"Epilepsy","enrollment":81}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"valproate microgranules","genericName":"valproate microgranules","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Valproate inhibits histone deacetylase and enhances GABAergic neurotransmission, leading to increased GABA levels and neuronal stabilization. Used for Epilepsy (seizure disorders), Bipolar disorder (acute mania), Migraine prophylaxis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}