{"id":"valerian-hop-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Valerian root contains compounds such as valerenic acid and sesquiterpenes that may enhance GABAergic neurotransmission and modulate serotonin pathways, while hops contribute bitter acids and flavonoids with sedative properties. Together, these botanical ingredients are traditionally used to improve sleep quality and reduce nervous tension without the potency of synthetic hypnotics.","oneSentence":"Valerian-hop extract promotes sleep and reduces anxiety through combined sedative and anxiolytic effects of its herbal constituents.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:54.678Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia and sleep disturbances"},{"name":"Anxiety and nervous tension"}]},"trialDetails":[{"nctId":"NCT05684523","phase":"PHASE4","title":"Feasibility Study on the Use of Redormin®500 on Day-time Cognition","status":"COMPLETED","sponsor":"Max Zeller Soehne AG","startDate":"2023-03-01","conditions":"Sleep Disorders, Circadian Rhythm, Cognitive Dysfunction","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Redormin® 500"],"phase":"marketed","status":"active","brandName":"Valerian-Hop Extract","genericName":"Valerian-Hop Extract","companyName":"Max Zeller Soehne AG","companyId":"max-zeller-soehne-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Valerian-hop extract promotes sleep and reduces anxiety through combined sedative and anxiolytic effects of its herbal constituents. Used for Insomnia and sleep disturbances, Anxiety and nervous tension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}