{"id":"vaginal-progesteron","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or discharge"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":{"setId":"473ab609-5b9e-3cb8-68d5-4a459a2ea6c1","title":"PROGESTERONE VAGINAL INSERT (PROGESTERONE) INSERT [ XIROMED, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone essential for preparing and maintaining the uterine endometrium for implantation and early pregnancy. Vaginal administration provides local and systemic progesterone levels to support the luteal phase, reduce miscarriage risk in certain populations, and prevent preterm labor. The vaginal route offers improved bioavailability and reduced hepatic metabolism compared to oral formulations.","oneSentence":"Vaginal progesterone delivers the hormone progesterone directly to the reproductive tract to support luteal phase function and maintain early pregnancy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:49:24.447Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART)"},{"name":"Prevention of preterm birth in singleton pregnancies with a history of preterm delivery"},{"name":"Recurrent pregnancy loss prevention"}]},"trialDetails":[{"nctId":"NCT07496294","phase":"NA","title":"Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone Therapy","status":"NOT_YET_RECRUITING","sponsor":"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","startDate":"2026-04","conditions":"Menopausal Women, Menopausal Symptom Relief, Hormone 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