{"id":"vaginal-conjugated-estrogen-cream-1-0gm","safety":{"commonSideEffects":[{"rate":"null","effect":"Vaginal bleeding"},{"rate":"null","effect":"Headache"},{"rate":"null","effect":"Breast tenderness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Vaginal conjugated estrogen cream works by releasing estrogen directly into the vagina, which helps to alleviate symptoms of menopause such as vaginal dryness and pain during sex. This is achieved by mimicking the natural estrogen levels in the body, promoting healthy vaginal tissue and reducing inflammation.","oneSentence":"Estrogen replacement therapy to alleviate menopausal symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:27.048Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause or breast cancer treatment"}]},"trialDetails":[{"nctId":"NCT00803335","phase":"PHASE3","title":"The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse","status":"COMPLETED","sponsor":"TriHealth Inc.","startDate":"2008-12","conditions":"Pelvic Organ Prolapse, Vaginal Atrophy","enrollment":54}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Premarin"],"phase":"phase_3","status":"active","brandName":"Vaginal conjugated estrogen cream 1.0gm","genericName":"Vaginal conjugated estrogen cream 1.0gm","companyName":"TriHealth Inc.","companyId":"trihealth-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estrogen replacement therapy to alleviate menopausal symptoms. Used for Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause or breast cancer treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}